ZFIN ID: ZDB-PUB-150625-2
Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis
Diotel, N., Beil, T., Strähle, U., Rastegar, S.
Date: 2015
Source: Gene expression patterns : GEP   19(1-2): 1-13 (Journal)
Registered Authors: Beil, Tanja, Diotel, Nicolas, Rastegar, Sepand, Strähle, Uwe
Keywords: Rp58 (znf238), adult neurogenesis, expression pattern, inhibitor of DNA binding (id), neural progenitor, radial glial cells, stem cell, telencephalon, teleost, zebrafish
MeSH Terms:
  • Adult Stem Cells/cytology
  • Adult Stem Cells/metabolism
  • Adult Stem Cells/physiology
  • Animals
  • Brain/metabolism
  • Brain/physiology
  • Cell Differentiation/genetics
  • Gene Expression Profiling
  • Inhibitor of Differentiation Proteins/biosynthesis
  • Inhibitor of Differentiation Proteins/genetics*
  • Neural Stem Cells/cytology
  • Neural Stem Cells/metabolism
  • Neural Stem Cells/physiology*
  • Neurogenesis/genetics*
  • Neurons/cytology
  • Neurons/metabolism
  • Neurons/physiology*
  • Repressor Proteins/biosynthesis
  • Repressor Proteins/genetics*
  • Zebrafish/genetics*
PubMed: 26107416 Full text @ Gene Expr. Patterns
Teleost fish display a remarkable ability to generate new neurons and to repair brain lesions during adulthood. They are, therefore, a very popular model to investigate the molecular mechanisms of constitutive and induced neurogenesis in adult vertebrates. In this study, we investigated the expression patterns of inhibitor of DNA binding (id) genes and of their potential transcriptional repressor, znf238, in the whole brain of adult zebrafish. We show that while id1 is exclusively expressed in ventricular cells in the whole brain, id2a, id3 and id4 genes are expressed in broader areas. Interestingly, znf238 was also detected in these regions, its expression overlapping with id2a, id3 and id4 expression. Further detailed characterization of the id-expressing cells demonstrated that (a) id1 is expressed in type 1 and type 2 neural progenitors as previously published, (b) id2a in type 1, 2 and 3 neural progenitors, (c) id3 in type 3 neural progenitors and (d) id4 in postmitotic neurons. Our data provide a detailed map of id and znf238 expression in the brain of adult zebrafish, supplying a framework for studies of id gene function during adult neurogenesis and brain regeneration in the zebrafish.