PUBLICATION
Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish
- Authors
- Cheng, C.N., Verdun, V.A., Wingert, R.A.
- ID
- ZDB-PUB-150530-1
- Date
- 2015
- Source
- Cells 4: 218-233 (Review)
- Registered Authors
- Cheng, Christina, Verdun, Valerie, Wingert, Rebecca
- Keywords
- aPKC, hnf1ba/b, kidney development, mecom, nephron segmentation, renal progenitor, sim1a, tubulogenesis, vertebrate, zebrafish
- MeSH Terms
- none
- PubMed
- 26024215 Full text @ Cells
Citation
Cheng, C.N., Verdun, V.A., Wingert, R.A. (2015) Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish. Cells. 4:218-233.
Abstract
The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal development. The zebrafish embryonic kidney serves as a simplified yet conserved vertebrate model to delineate how nephron segments are patterned from renal progenitors. Here, we provide a concise review of recent advances in this emerging field, and discuss how continued research using zebrafish genetics can be applied to gain insights about nephrogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping