Ribbon Synapses in Zebrafish Hair Cells
- Nicolson, T.
- Hearing Research 330(Pt B): 170-7 (Review)
- Registered Authors
- Nicolson, Teresa
- Cav1.3a, Rbc3a, Ribeye, Synj1, Vglut3, hair cell, ribbon synapses, zebrafish
- MeSH Terms
- Animals, Genetically Modified
- Auditory Pathways/physiology
- Calcium Signaling
- Hair Cells, Auditory/metabolism
- Hair Cells, Auditory/physiology*
- Mechanotransduction, Cellular
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Synaptic Transmission*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- 25916266 Full text @ Hear. Res.
Nicolson, T. (2015) Ribbon Synapses in Zebrafish Hair Cells. Hearing Research. 330(Pt B):170-7.
The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes