PUBLICATION
Ribbon Synapses in Zebrafish Hair Cells
- Authors
- Nicolson, T.
- ID
- ZDB-PUB-150429-5
- Date
- 2015
- Source
- Hearing Research 330(Pt B): 170-7 (Review)
- Registered Authors
- Nicolson, Teresa
- Keywords
- Cav1.3a, Rbc3a, Ribeye, Synj1, Vglut3, hair cell, ribbon synapses, zebrafish
- MeSH Terms
-
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Calcium Signaling
- Phenotype
- Animals
- Auditory Pathways/physiology
- Hair Cells, Auditory/metabolism
- Hair Cells, Auditory/physiology*
- Hearing
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Synaptic Transmission*
- Mechanotransduction, Cellular
- Genotype
- Animals, Genetically Modified
- PubMed
- 25916266 Full text @ Hear. Res.
Citation
Nicolson, T. (2015) Ribbon Synapses in Zebrafish Hair Cells. Hearing Research. 330(Pt B):170-7.
Abstract
The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping