PUBLICATION

Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry

Authors
Yuan, S., Zhao, L., Brueckner, M., Sun, Z.
ID
ZDB-PUB-150211-27
Date
2015
Source
Current biology : CB   25(5): 556-67 (Journal)
Registered Authors
Sun, Zhaoxia, Yuan, Shiaulou
Keywords
none
MeSH Terms
  • ADP-Ribosylation Factors/metabolism
  • Analysis of Variance
  • Animals
  • Body Patterning/physiology*
  • Calcium Signaling/physiology*
  • Cilia/metabolism*
  • Extracellular Fluid/metabolism
  • Heterotaxy Syndrome/embryology*
  • Histological Techniques
  • Humans
  • Models, Biological
  • Nodal Signaling Ligands/metabolism
  • Signal Transduction/physiology*
  • TRPP Cation Channels/metabolism
  • Zebrafish/embryology*
  • Zebrafish Proteins/metabolism
PubMed
25660539 Full text @ Curr. Biol.
Abstract
Bilateral symmetry during vertebrate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid. However, how ciliary motility is perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial. Previous work has indicated that sensory cilia and polycystin-2 (Pkd2), a cation channel, are required for sensing ciliary motility, yet their function and the molecular mechanism linking both to left-right signaling cascades are unknown.
Here we report novel intraciliary calcium oscillations (ICOs) at the LRO that connect ciliary sensation of ciliary motility to downstream left-right signaling. Utilizing cilia-targeted genetically encoded calcium indicators in live zebrafish embryos, we show that ICOs depend on Pkd2 and are left-biased at the LRO in response to ciliary motility. Asymmetric ICOs occur with onset of LRO ciliary motility, thus representing the earliest known LR asymmetric molecular signal. Suppression of ICOs using a cilia-targeted calcium sink reveals that they are essential for LR development.
These findings demonstrate that intraciliary calcium initiates LR development and identify cilia as a functional ion signaling compartment connecting ciliary motility and flow to molecular LR signaling.
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