PUBLICATION
The helix-loop-helix protein Id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon
- Authors
- Rodriguez Viales, R., Diotel, N., Ferg, M., Armant, O., Eich, J., Alunni, A., März, M., Bally-Cuif, L., Rastegar, S., Strähle, U.
- ID
- ZDB-PUB-141108-11
- Date
- 2015
- Source
- Stem cells (Dayton, Ohio) 33(3): 892-903 (Journal)
- Registered Authors
- Alunni, Violaine, Armant, Olivier, Bally-Cuif, Laure, Diotel, Nicolas, Eich, Julia, Ferg, Marco, Rastegar, Sepand, Rodriguez Viales, Rebecca, Strähle, Uwe
- Keywords
- expression atlas, id1, reactive neurogenesis, telencephalon, transcription regulators, zebrafish
- MeSH Terms
-
- Animals
- Neuroglia/cytology*
- Neuroglia/metabolism
- Inhibitor of Differentiation Protein 2/genetics
- Inhibitor of Differentiation Protein 2/metabolism
- Inhibitor of Differentiation Protein 2/physiology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish/physiology*
- Telencephalon/metabolism
- Telencephalon/physiology*
- Neurogenesis/physiology*
- Cell Proliferation/physiology
- Brain/cytology*
- Brain/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Zebrafish Proteins/physiology*
- PubMed
- 25376791 Full text @ Stem Cells
Citation
Rodriguez Viales, R., Diotel, N., Ferg, M., Armant, O., Eich, J., Alunni, A., März, M., Bally-Cuif, L., Rastegar, S., Strähle, U. (2015) The helix-loop-helix protein Id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Stem cells (Dayton, Ohio). 33(3):892-903.
Abstract
The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators (TRs), the id1 gene, encoding a negative regulator of E-proteins, was found to be up-regulated in response to injury. id1 expression was mapped to quiescent type I neural stem cells in the adult telencephalic stem cell niche. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals, suggesting multiple antagonistic pathways in the regulation of reactive neurogenesis. Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals. Stem Cells 2014.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping