PUBLICATION
Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio)
- Authors
- Eisa-Beygi, S., Macdonald, R.L., Wen, X.Y.
- ID
- ZDB-PUB-140717-5
- Date
- 2014
- Source
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 34(9): 1430-3 (Review)
- Registered Authors
- Eisa-Beygi, Shahram
- Keywords
- none
- MeSH Terms
-
- Aneurysm/genetics
- Aneurysm/metabolism
- Aneurysm/pathology
- Animals
- Antigens, CD/genetics
- Antigens, CD/metabolism*
- Cadherins/genetics
- Cadherins/metabolism*
- Cell Adhesion/genetics
- Disease Models, Animal
- Endothelial Cells/metabolism*
- Endothelial Cells/pathology
- Hemangioma, Cavernous, Central Nervous System/genetics
- Hemangioma, Cavernous, Central Nervous System/metabolism
- Hemangioma, Cavernous, Central Nervous System/pathology
- Zebrafish/genetics
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 25027310 Full text @ J. Cereb. Blood Flow Metab.
Citation
Eisa-Beygi, S., Macdonald, R.L., Wen, X.Y. (2014) Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio). Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(9):1430-3.
Abstract
The endothelial-specific transmembrane glycoprotein, vascular endothelial (VE)-cadherin, is required for the organization of a stable vascular endothelium. A number of cerebrovascular disorders are associated with mutations in genes that otherwise regulate vascular integrity through VE-cadherin dynamics. Hence, identification and characterization of regulatory pathways contributing to endothelial cell-cell adhesion is of clinical relevance, particularly in the treatment of aneurysms and cerebral cavernous malformations. The zebrafish (Danio rerio) have recently emerged as a powerful paradigm for studies geared toward elucidating the etiology of cerebrovascular disorders, principally in uncovering the genetic and mechanistic basis controlling endothelial adhesive barrier function.Journal of Cerebral Blood Flow & Metabolism advance online publication, 16 July 2014; doi:10.1038/jcbfm.2014.128.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping