PUBLICATION

Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio)

Authors
Eisa-Beygi, S., Macdonald, R.L., Wen, X.Y.
ID
ZDB-PUB-140717-5
Date
2014
Source
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   34(9): 1430-3 (Review)
Registered Authors
Eisa-Beygi, Shahram
Keywords
none
MeSH Terms
  • Aneurysm/genetics
  • Aneurysm/metabolism
  • Aneurysm/pathology
  • Animals
  • Antigens, CD/genetics
  • Antigens, CD/metabolism*
  • Cadherins/genetics
  • Cadherins/metabolism*
  • Cell Adhesion/genetics
  • Disease Models, Animal
  • Endothelial Cells/metabolism*
  • Endothelial Cells/pathology
  • Hemangioma, Cavernous, Central Nervous System/genetics
  • Hemangioma, Cavernous, Central Nervous System/metabolism
  • Hemangioma, Cavernous, Central Nervous System/pathology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed
25027310 Full text @ J. Cereb. Blood Flow Metab.
Abstract
The endothelial-specific transmembrane glycoprotein, vascular endothelial (VE)-cadherin, is required for the organization of a stable vascular endothelium. A number of cerebrovascular disorders are associated with mutations in genes that otherwise regulate vascular integrity through VE-cadherin dynamics. Hence, identification and characterization of regulatory pathways contributing to endothelial cell-cell adhesion is of clinical relevance, particularly in the treatment of aneurysms and cerebral cavernous malformations. The zebrafish (Danio rerio) have recently emerged as a powerful paradigm for studies geared toward elucidating the etiology of cerebrovascular disorders, principally in uncovering the genetic and mechanistic basis controlling endothelial adhesive barrier function.Journal of Cerebral Blood Flow & Metabolism advance online publication, 16 July 2014; doi:10.1038/jcbfm.2014.128.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping