PUBLICATION
Zebrafish as a model to explore cell metabolism
- Authors
- Santoro, M.M.
- ID
- ZDB-PUB-140707-2
- Date
- 2014
- Source
- Trends in endocrinology and metabolism: TEM 25(10): 546-554 (Review)
- Registered Authors
- Santoro, Massimo
- Keywords
- drug screening, genetics, metabolic disorders, metabolomics, tools, zebrafish
- MeSH Terms
-
- Animals
- Cells/metabolism*
- Humans
- Models, Biological*
- Zebrafish/genetics
- Zebrafish/metabolism
- PubMed
- 24997878 Full text @ Trends Endocrinol. Metab.
Citation
Santoro, M.M. (2014) Zebrafish as a model to explore cell metabolism. Trends in endocrinology and metabolism: TEM. 25(10):546-554.
Abstract
Cell metabolism plays a key role in many essential biological processes. The recent availability of novel technologies and organisms to model cell metabolism in vivo is expanding current knowledge of cell metabolism. In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for cellular homeostasis. Here, the most recent methods and studies on cell metabolism are summarized, which support the overall value for the zebrafish model system not only to study metabolism but also metabolic disease states. It is envisioned that this small vertebrate system will help in the understanding of pathogenesis for numerous metabolic-related disorders in humans and in the identification of their therapeutic treatments.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping