PUBLICATION

Development of the lateral line canal system through a bone remodeling process in zebrafish

Authors
Wada, H., Iwasaki, M., Kawakami, K.
ID
ZDB-PUB-140520-9
Date
2014
Source
Developmental Biology   392(1): 1-14 (Journal)
Registered Authors
Kawakami, Koichi, Wada, Hironori
Keywords
Bone remodeling, Lateral line, Neuromast, Organ growth, Scale, Zebrafish
MeSH Terms
  • Alkaline Phosphatase/biosynthesis
  • Alkaline Phosphatase/metabolism
  • Osteoblasts/metabolism
  • Intercellular Signaling Peptides and Proteins/genetics
  • Intercellular Signaling Peptides and Proteins/metabolism
  • Receptor, Macrophage Colony-Stimulating Factor/genetics
  • Animals, Genetically Modified
  • Integumentary System
  • Lateral Line System/cytology*
  • Lateral Line System/embryology*
  • Animals
  • Osteoclasts/metabolism
  • Bone and Bones/embryology
  • Zebrafish/embryology*
  • Embryonic Development
  • Wnt Signaling Pathway
  • Transcription Factors/biosynthesis
  • Bone Remodeling/physiology*
  • Zebrafish Proteins/biosynthesis
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
(all 21)
PubMed
24836859 Full text @ Dev. Biol.
Abstract
The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues.
Genes / Markers
Figures
Figure Gallery (15 images) / 2
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
j4e1
    		Point Mutation
    kyu1TgTransgenic Insertion
      nkgSAzGFF15ATgTransgenic Insertion
        nksagfflf228aTgTransgenic Insertion
          nns8TgTransgenic Insertion
            t1
              		Point Mutation
              zf106TgTransgenic Insertion
                1 - 7 of 7
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                Human Disease / Model
                No data available
                Sequence Targeting Reagents
                No data available
                Fish
                Fish
                csf1raj4e1/j4e1
                gja5bt1
                kyu1Tg
                nkgSAzGFF15ATg
                nksagfflf228aTg
                nns8Tg
                zf106Tg
                1 - 7 of 7
                Show
                Antibodies
                No data available
                Orthology
                No data available
                Engineered Foreign Genes
                Marker Marker Type Name
                d2EGFPEFGd2EGFP
                EGFPEFGEGFP
                GAL4FFEFGGAL4FF
                TomatoEFGTomato
                1 - 4 of 4
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                Mapping
                No data available
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                Citation
                Wada, H., Iwasaki, M., Kawakami, K. (2014) Development of the lateral line canal system through a bone remodeling process in zebrafish. Developmental Biology. 392(1):1-14.