|ZFIN ID: ZDB-PUB-140513-147|
Your Input Welcome
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies
Eisa-Beygi, S., Ekker, M., Moon, T.W., Macdonald, R.L., Wen, X.Y.
|Source:||Reproductive toxicology (Elmsford, N.Y.) 46C: 115-120 (Review)|
|Registered Authors:||Eisa-Beygi, Shahram, Ekker, Marc|
|Keywords:||Cholesterol, Development, HMGCR, Prenylation, Statins, Teratogenesis, Toxicity|
|PubMed:||24732207 Full text @ Reprod. Toxicol.|
Eisa-Beygi, S., Ekker, M., Moon, T.W., Macdonald, R.L., Wen, X.Y. (2014) Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies. Reproductive toxicology (Elmsford, N.Y.). 46C:115-120.
ABSTRACTThe 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in the biosynthesis of cholesterol and isoprenoids, which are substrates required for post-translational modification of signalling proteins that can potentially regulate various aspects of embryonic development. The HMGCR transcripts are detectable during early embryogenesis in both invertebrates and vertebrates, which suggests a conserved developmental requirement for mevalonate derivatives. Consistently, recent animal and in vitro studies have yielded valuable insights into potential morphogenic parameters that are modulated by HMGCR activity. These developmental end-points include brain and craniofacial morphogenesis, PGC migration and survival, myocardial epithelial migration and fusion, EC migration and survival, and vascular stabilization. By providing a synthesis of these studies, we hope that this review will highlight the need to comprehensively examine the entire suite of developmental processes regulated by HMGCR.
ADDITIONAL INFORMATION No data available