PUBLICATION
A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay
- Authors
- Chamakuri, S., Guduru, S.K., Pamu, S., Chandrasekar, G., Kitambi, S.S., and Arya, P.
- ID
- ZDB-PUB-140325-8
- Date
- 2013
- Source
- European Journal of Organic Chemistry 2013(19): 3959-3964 (Journal)
- Registered Authors
- Kitambi, Satish Srinivas
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none Full text @ Eur. J. Org. Chem.
Citation
Chamakuri, S., Guduru, S.K., Pamu, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay. European Journal of Organic Chemistry. 2013(19):3959-3964.
Abstract
A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent “stitching technology”. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping