ZFIN ID: ZDB-PERS-060815-1
Kitambi, Satish Srinivas
Email: satish.kitambi@ki.se
URL: http://www.ki.se, www.k-lifesolutions.com
Affiliation:
Address:
Country:
Phone: 0046 8-52487661
Fax: 0046 8 6084510
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Yin, C., Fufa, T., Chandrasekar, G., Aeluri, M., Zaky, V., Abdelhady, S., Rodríguez, A.B., Jakobsson, J., Varnoosfaderani, F.S., Mahalingam, J., Liu, J., Larsson, O., Hovatta, O., Gaunitz, F., Göndör, A., Andäng, M., Kitambi, S.S. (2017) Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation. Frontiers in pharmacology. 8:726
Szabo, M., Svensson Akusjärvi, S., Saxena, A., Liu, J., Chandrasekar, G., Kitambi, S.S. (2017) Cell and small animal models for phenotypic drug discovery. Drug design, development and therapy. 11:1957-1967
Hammarström, L.G., Harmel, R.K., Granath, M., Ringom, R., Gravenfors, Y., Färnegårdh, K., Svensson, P.H., Wennman, D., Lundin, G., Roddis, Y., Kitambi, S.S., Bernlind, A., Lehmann, F., Ernfors, P. (2016) The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features. Journal of medicinal chemistry. 59:8577-92
Theofilopoulos, S., Griffiths, W.J., Crick, P.J., Yang, S., Meljon, A., Ogundare, M., Kitambi, S.S., Lockhart, A., Tuschl, K., Clayton, P.T., Morris, A.A., Martinez, A., Reddy, M.A., Martinuzzi, A., Bassi, M.T., Honda, A., Mizuochi, T., Kimura, A., Nittono, H., De Michele, G., Carbone, R., Criscuolo, C., Yau, J.L., Seckl, J.R., Schüle, R., Schöls, L., Sailer, A.W., Kuhle, J., Fraidakis, M.J., Gustafsson, J.A., Steffensen, K.R., Björkhem, I., Ernfors, P., Sjövall, J., Arenas, E., Wang, Y. (2014) Cholestenoic acids regulate motor neuron survival via liver X receptors. J. Clin. Invest.. 124(11):4829-42
Chamakuri, S., Guduru, S.K., Pamu, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay. European Journal of Organic Chemistry. 2013(19):3959-3964
Aeluri, M., Gaddam, J., Trinath, D.V., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay. European Journal of Organic Chemistry. 2013(19):3955-3958
Reddy Guduru, S.K., Chamakuri, S., Chandrasekar, G., Kitambi, S.S., Arya, P. (2013) Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay. ACS Medicinal Chemistry Letters. 4:666-70
Aeluri, M., Pramanik, C., Chetia, L., Mallurwar, N.K., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) 14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay. Organic letters. 15(3):436-439
Theofilopoulos, S., Wang, Y., Kitambi, S.S., Sacchetti, P., Sousa, K.M., Bodin, K., Kirk, J., Saltó, C., Gustafsson, M., Toledo, E.M., Karu, K., Gustafsson, J.A., Steffensen, K.R., Ernfors, P., Sjövall, J., Griffiths, W.J., and Arenas, E. (2013) Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology. 9(2):126-133
Dasari, B., Jogula, S., Borhade, R., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay. Organic letters. 15(3):432-435
Archer, A., Kitambi, S.S., Hallgren, S.L., Pedrelli, M., Olsen, K.H., Mode, A., and Gustafsson, J.A. (2012) The Liver X-Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development. Open journal of endocrine and metabolic diseases. 2(4):74-81
Kitambi, S.S., Nilsson, E.S., Sekyrova, P., Ibarra, C., Nyah Tekeoh, G., Andang, M., Ernfors, P., and Uhlen, P. (2012) Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart. BMC Physiology. 12(1):3
Chandrasekar, G., Arner, A., Kitambi, S.S., Dahlman-Wright, K., and Lendahl, M.A. (2011) Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish. Neurotoxicology and teratology. 33(6):752-64
Kitambi, S.S., Chandrasekar, G., and Addanki, V.K. (2011) Teleost fish – powerful models for studying development, function and diseases of the human eye. Current science. 100(12):1815-1823
Kitambi, S.S., McCulloch, K.J., Peterson, R.T., and Malicki, J.J. (2009) Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mechanisms of Development. 126(5-6):464-477
Kitambi, S.S. (2009) Teleost retina : a model for study neurogenesis and angiogenesis. Ph.D. Thesis. :37p
Kitambi, S.S., and Malicki, J.J. (2008) Spatiotemporal features of neurogenesis in the retina of medaka, Oryzias latipes. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3870-3881
Kitambi, S.S., and Hauptmann, G. (2007) The zebrafish orphan nuclear receptor genes nr2e1 and nr2e3 are expressed in developing eye and forebrain. Gene expression patterns : GEP. 7(4):521-528

NON-ZEBRAFISH PUBLICATIONS
1) Theofilopoulos, S., Wang, Y.Q., Kitambi, S.S., Sacchetti, P., Sousa, K.M., Bodin, K., Kirk, J., Salto, C., Gustafsson, M., Toledo, E.M., et al. (2013). Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology 9, 126-133.

2) Guduru, S.K.R., Chamakuri, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013). Tetrahydroquinoline-Derived Macrocyclic Toolbox: The Discovery of Antiangiogenesis Agents in Zebrafish Assay. Acs Med Chem Lett 4, 101-105. (Co-Corresponding Author)

3) Dasari, B., Jogula, S., Borhade, R., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013). Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay. Organic Letters 15, 432-435. (Co-Corresponding Author)

4) Chamakuri, S., Guduru, S.K.R., Pamu, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013). A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay. Eur J Org Chem, 3959-3964. (Co-Corresponding Author)

5) Aeluri, M., Pramanik, C., Chetia, L., Mallurwar, N.K., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013). 14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay. Organic Letters 15, 436-439. (Co-Corresponding Author)

6) Aeluri, M., Gaddam, J., Trinath, D.V.K.S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013). An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay. Eur J Org Chem, 3955-3958. (Co-Corresponding Author)

7) Abdelhady, S., Kitambi, S.S., Lundin, V., Aufschnaiter, R., Sekyrova, P., Sinha, I., Lundgren, K.T., Castelo-Branco, G., Linnarsson, S., Wedlich-Soldner, R., et al. (2013). Erg Channel Is Critical in Controlling Cell Volume during Cell Cycle in Embryonic Stem Cells. PloS one 8 (8).

8) Kitambi, S.S., Nilsson, E., Sekyrova, P., Ibarra, C., Tekeoh, G.N., Andang, M., Ernfors, P., and Uhlen, P. (2012). Small Molecule Screening Platform for Assessment of Cardiovascular Toxicity on Adult Zebrafish Heart. BMC Physiology 12. (Corresponding Author)

9) Adameyko, I., Lallemend, F., Furlan, A., Zinin, N., Aranda, S., Kitambi, S.S., Blanchart, A., Favaro, R., Nicolis, S., Lubke, M., et al. (2012). Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 139, 397-410.

10) Archer A, Kitambi SS, Hallgren S, Pedrelli M, Olsen H, Mode A, Jan-�ke Gustafsson (2012). The Liver X Receptor governs lipid homeostasis in zebrafish during development. OJEMD 2, 74-81.

11) Kitambi, S.S., Chandrasekar, G., and Addanki, V.K. (2011). Teleost fish - powerful models for studying development, function and diseases of the human eye. CURRENT SCIENCE 100, 1815-1823. (Corresponding Author)

12) Chandrasekar, G., Arner, A., Kitambi, S.S., Dahlman-Wright, K., and Lendahl, M.A. (2011). Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish. Neurotoxicol Teratol 33, 752-764.

13) Kitambi SS and Chandrasekar G (2011), Stem cells and animal models in screening, identification, development of drugs. Stem Cells and Cloning: Advances and Applications 4, 51-59. (Corresponding Author)

14) Kitambi, S.S., McCulloch, K.J., Peterson, R.T., and Malicki, J.J. (2009). Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mechanisms of development 126, 464-477.

15) Kitambi, S.S., and Malicki, J.J. (2008). Spatiotemporal features of neurogenesis in the retina of medaka, Oryzias latipes. Dev Dyn 237, 3870-3881.

16) Kitambi, S.S., and Hauptmann, G. (2007). The zebrafish orphan nuclear receptor genes nr2e1 and nr2e3 are expressed in developing eye and forebrain. Gene Expr Patterns 7, 521-528.

17) Srivastava, R., Kitambi, S.S., and Goyal, A. (2005). In Silico Analysis of Thioredoxins and Glutaredoxins. Journal of Plant Biochemistry and Biotechnology 14, 121-126.

18) Srivastava, R., Kitambi, S.S., and Amla, D.V. (2004). Analysis of Glutamine Synthetase (glnA) Gene from Prokaryotic and Eukaryotic Organisms. Physiology and Molecular Biology of Plants 10(2), 197-202.

19) Kitambi, S.S., Chandrasekar, G., Srivastava, R., and Puvanakrishnan, R. (2004). A novel protocol for the subcellular fractionation of C3A hepatoma cells using sucrose density gradient centrifugation. Journal of biochemical and biophysical methods 60, 23-27.