PUBLICATION

A fisheye view on lymphangiogenesis

Authors
van Impel, A., and Schulte-Merker, S.
ID
ZDB-PUB-140113-9
Date
2014
Source
Advances in anatomy, embryology, and cell biology   214: 153-65 (Chapter)
Registered Authors
Schulte-Merker, Stefan, van Impel, Andreas
Keywords
none
MeSH Terms
  • Animals
  • Calcium-Binding Proteins/metabolism*
  • Lymphangiogenesis*
  • Lymphatic Vessels/embryology*
  • Lymphatic Vessels/metabolism
  • Lymphedema/genetics
  • Mice
  • Tumor Suppressor Proteins/metabolism*
  • Vascular Endothelial Growth Factor C/metabolism*
  • Vascular Endothelial Growth Factor Receptor-3/metabolism*
  • Zebrafish
PubMed
24276893 Full text @ Adv. Anat. Embryol. Cell Biol.
Abstract

Zebrafish have been widely used to study vasculogenesis and angiogenesis, and the vascular system is one of the most intensively studied organ systems in teleosts. It is a little surprising, therefore, that the development of the zebrafish lymphatic network has only been investigated in any detail for less than a decade now. In those last few years, however, significant progress has been made. Due to favorable imaging possibilities within the early zebrafish embryo, we have a very good understanding of what cellular behavior accompanies the formation of the lymphatic system and which cells within the vasculature are destined to contribute to lymphatic vessels. The migration routes of future lymphatic endothelial cells have been monitored in great detail, and a number of transgenic lines have been developed that help to distinguish between arterial, venous, and lymphatic fates in vivo. Furthermore, both forward and reverse genetic tools have been systematically employed to unravel which genes are involved in the process. Not surprisingly, a number of known players were identified (such as vegfc and flt4), but work on zebrafish has also distinguished genes and proteins that had not previously been connected to lymphangiogenesis. Here, we will review these topics and also compare the equivalent stages of lymphatic development in zebrafish and mice. We will, in addition, highlight some of those studies in zebrafish that have helped to identify and to further characterize human disease conditions.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes