Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain
- Authors
- Kishimoto, N., Asakawa, K., Madelaine, R., Blader, P., Kawakami, K., and Sawamoto, K.
- ID
- ZDB-PUB-130611-37
- Date
- 2013
- Source
- Nature Neuroscience 16(7): 884-8 (Journal)
- Registered Authors
- Blader, Patrick, Kawakami, Koichi, Kishimoto, Norihito, Madelaine, Romain
- Keywords
- none
- MeSH Terms
-
- Enzyme Inhibitors/pharmacology
- Injections, Intraventricular
- Age Factors
- Dipeptides/pharmacology
- Locomotion/drug effects
- Locomotion/physiology
- Epithelium/injuries
- Epithelium/physiology
- Catheter Ablation
- Animals, Genetically Modified
- Odorants
- Olfactory Pathways/cytology
- Olfactory Pathways/physiology*
- Neurons/physiology*
- Olfactory Bulb/cytology*
- Olfactory Bulb/physiology
- Amino Acids/metabolism
- Amino Acids/pharmacology
- Nerve Tissue Proteins/metabolism
- Zebrafish
- Zebrafish Proteins/genetics
- Animals
- Functional Laterality/genetics
- Functional Laterality/physiology*
- Dose-Response Relationship, Drug
- Cerebral Ventricles/metabolism
- HSP70 Heat-Shock Proteins/metabolism
- Green Fluorescent Proteins/genetics
- Green Fluorescent Proteins/metabolism
- PubMed
- 23685722 Full text @ Nat. Neurosci.
The vertebrate brain is anatomically and functionally asymmetric. The left and right cerebral hemispheres harbor neural stem cell niches at the ventricular-subventricular zone (V-SVZ) of the ventricular walls, where new neurons are continuously generated throughout life. However, any interhemispheric asymmetry of neural stem cell niches remains unclear. We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons expressing the neural zinc-finger protein Myt1 exist predominantly in the left V-SVZ. This lateralization could be reversed by left olfactory sensory deprivation–induced inactivation of Notch signaling. The olfactory behavioral preference for attractive amino acids was also impaired by sensory deprivation of the left olfactory system, but not of the right olfactory system. Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain.