Rodríguez-Aznar, E., Barrallo-Gimeno, A., and Nieto, M.A. (2013) Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(12):5095-5105.
During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked.
Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration
and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show
that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo.
scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels
of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic
primary neurons by preventing cell cycle re-entry.