|ZFIN ID: ZDB-PERS-110912-1|
BIOGRAPHY AND RESEARCH INTERESTS
M. Angela Nieto, Ph.D., is Full Professor and Head of the Developmental Neurobiology Unit at the Instituto de Neurociencias (CSIC-UMH) in Alicante, Spain. She received her PhD in 1987 from the Universidad Autónoma (UAM) in Madrid. After a postdoct at the Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), she moved to the National Institute for Medical Research in London to work with David Wilkinson where she isolated a number of genes involved in the morphogenesis of the nervous system. In 1993, she obtained a position of Staff Scientist at the Cajal Institute in Madrid. From then on, she has led a research group interested in cell movements and adhesion in the early vertebrate embryo. Her main contribution has been the isolation and characterization of the Snail gene family, showing its role in the formation of different tissues and organs during embryonic development and how its reactivation at late developmental times or in the adult leads to several pathologies, including tumor progression, fibrosis and defects in bone development and mineralization. She was elected EMBO member in 2000 and Member of the Academy of Europe in 2009. Among others, she has received the Carmen and Severo Ochoa Prize (2004), the Francisco Cobos Foundation Prize in Biomedical Research (2005) and the Rey Jaime I Prize in Basic Research (2009). She is member of the Editorial Boards of EMBO J, EMBO reports; Current Opinion in Genetics and Development; Mechanism of Development; Gene Expression Patterns and Int. J. Developmental Biology. She is the President of the Spanish Society for Developmental Biology, a member of the Board of directors of the International Society of Differentiation and the Spanish delegate for EMBO/EMBC/EMBL.
Castroviejo, N., Ocaña, O.H., Rago, L., Coskun, H., Arcas, A., Galcerán, J., Nieto, M.A. (2020) Reply to: Zebrafish prrx1a mutants have normal hearts. Nature. 585:E17-E19
Rago, L., Castroviejo, N., Fazilaty, H., Garcia-Asencio, F., Ocaña, O.H., Galcerán, J., Nieto, M.A. (2019) MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Developmental Cell. 51:446-459.e5
Fazilaty, H., Rago, L., Kass Youssef, K., Ocaña, O.H., Garcia-Asencio, F., Arcas, A., Galceran, J., Nieto, M.A. (2019) A gene regulatory network to control EMT programs in development and disease. Nature communications. 10:5115
Ocaña, O.H., Coskun, H., Minguillón, C., Murawala, P., Tanaka, E.M., Galcerán, J., Muñoz-Chápuli, R., Nieto, M.A. (2017) A right-handed signalling pathway drives heart looping in vertebrates. Nature. 549:86-90
Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474
Rodríguez-Aznar, E., Barrallo-Gimeno, A., and Nieto, M.A. (2013) Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(12):5095-5105
Ocaña, O.H., Córcoles, R., Fabra, A., Moreno-Bueno, G., Acloque, H., Vega, S.,Barrallo-Gimeno, A., Cano, A., Nieto, M.A. (2012) Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1. Cancer Cell. 22(6):709-724
Zhang, K., Rodriguez-Aznar, E., Yabuta, N., Owen, R.J., Mingot, J.M., Nojima, H., Nieto, M.A., and Longmore, G.D. (2012) Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. The EMBO journal. 31(1):29-43
Rodríguez-Aznar, E., and Nieto, M.A. (2011) Repression of Puma by Scratch2 is required for neuronal survival during embryonic development. Cell death and differentiation. 18(7):1196-207
Blanco, M.J., Barrallo-Gimeno, A., Acloque, H., Reyes, A.E., Tada, M., Allende, M.L., Mayor, R., and Nieto, M.A. (2007) Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (Cambridge, England). 134(22):4073-4081
Manzanares, M., Blanco, M.J., and Nieto, M.A. (2004) Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Development genes and evolution. 214(1):47-53
Locascio, A., Manzanares, M., Blanco, M.J., and Nieto, M.A. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16841-16846
Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell. 2016 Jun
30;166(1):21-45. doi: 10.1016/j.cell.2016.06.028. Review. PubMed PMID: 27368099.
Nieto MA. Epithelial plasticity: a common theme in embryonic and cancer cells.
Science. 2013 Nov 8;342(6159):1234850. doi: 10.1126/science.1234850. Review.
PubMed PMID: 24202173.