PUBLICATION
Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish
- Authors
- Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W.
- ID
- ZDB-PUB-130322-2
- Date
- 2013
- Source
- Leukemia 27(9): 1913-7 (Other)
- Registered Authors
- Li, Li, Zhang, Yiyue
- Keywords
- none
- MeSH Terms
-
- Proto-Oncogene Proteins/genetics*
- Proto-Oncogene Proteins/metabolism
- Myelopoiesis/genetics*
- Trans-Activators/genetics*
- Trans-Activators/metabolism
- Gene Expression Regulation
- Cell Line
- Mutation
- Zebrafish/genetics*
- Zebrafish/metabolism
- Animals
- PubMed
- 23455395 Full text @ Leukemia
Citation
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W. (2013) Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish. Leukemia. 27(9):1913-7.
Abstract
PU.1 is a member of Ets-family transcription factors, which is indispensable for generating early myeloid progenitors and for the determination of monocytic versus granulocytic lineages during myelopoiesis. Apart from its early function in myelopoiesis, PU.1 is also reported to be involved in leukemogenesis in mice and human. It has been shown that PU.1 expression is downregulated in human acute myeloid leukemia (AML) patients, and PU.1 mutations are found in about 7% of the patients in a study involving 126 AML patients. Likewise, reduction of PU.1 activity leads to AML in mice.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping