ZFIN ID: ZDB-PERS-180601-1
Li, Li
Email: swu_lili@126.com
Affiliation: Li Li Lab
Address: Key Laboratory of Freshwater Fish Resource, Reproduction and Development (MOE), School of Life Sciences, Southwest University 2 Tiansheng Road, Beibei 400715 Chongqing
Country: China
Phone: +86-23- 68254946
Fax: +86-23- 68253005

Fudan University (June 2005, MBBS), Hongkong University of Science and Technology (June 2011, Ph.D.), Hongkong University of Science and Technology (June 2011-Feb 2012, Post-doc), Southwest University (From Feb 2012, Professor).

We are interested in 1) development and regulation mechanisms of blood cells, 2) behaviors, functions and mechanisms of macrophages and granulocytes in innate immunity and tissue regeneration.

He, J., Zhao, F., Chen, B., Cui, N., Li, Z., Qin, J., Luo, L., Zhao, C., Li, L. (2023) Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution. Science China. Life sciences. 66(6):1358-1378
Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117
Zou, D., Qin, J., Hu, W., Wei, Z., Zhan, Y., He, Y., Zhao, C., Li, L. (2022) Macrophages Rapidly Seal off the Punctured Zebrafish Larval Brain through a Vital Honeycomb Network Structure. International Journal of Molecular Sciences. 23(18)
Jin, B., Xie, L., Zhan, D., Zhou, L., Feng, Z., He, J., Qin, J., Zhao, C., Luo, L., Li, L. (2022) Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase. Development (Cambridge, England). 149(17)
Zhao, F., Lu, Y., Li, Z., He, J., Cui, N., Luo, L., Li, L. (2022) The CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration. Journal of genetics and genomics = Yi chuan xue bao. 49(12):1138-1150
Zou, D., Hu, W., Qin, J., Wei, Z., Wang, D., Li, L. (2021) Rapid orderly migration of neutrophils after traumatic brain injury depends on MMP9/13. Biochemical and Biophysical Research Communications. 579:161-167
Zhang, C., Huang, R., Ma, X., Chen, J., Han, X., Li, L., Luo, L., Ruan, H., Huang, H. (2021) The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish. Frontiers in cell and developmental biology. 9:704730
Feng, Z., Lin, C., Tu, L., Su, M., Song, C., Liu, S., Suryanto, M.E., Hsiao, C.D., Li, L. (2021) FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish. Cells. 10(8):
Luo, J., Lu, C., Feng, M., Dai, L., Wang, M., Qiu, Y., Zheng, H., Liu, Y., Li, L., Tang, B., Xu, C., Wang, Y., Yang, X. (2021) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Journal of experimental & clinical cancer research : CR. 40:262
Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163
Yi, X., Yu, J., Ma, C., Dong, G., Shi, W., Li, H., Li, L., Luo, L., Sampath, K., Ruan, H., Huang, H. (2019) The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish. PLoS Genetics. 15:e1007408
Zhan, Y., Huang, Y., Chen, J., Cao, Z., He, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2018) The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao.
Yi, X., Yu, J., Ma, C., Li, L., Luo, L., Li, H., Ruan, H., Huang, H. (2018) Yap1/Taz are essential for the liver development in zebrafish. Biochemical and Biophysical Research Communications. 503(1):131-137
Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158
Yu, T., Guo, W., Tian, Y., Xu, J., Chen, J., Li, L., Wen, Z. (2017) Distinct regulatory networks control the development of macrophages of different origins in zebrafish. Blood. 129(4):509-519
Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853
Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., Zhang, Y. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26
Chen, J., He, J., Li, L., Yang, D., Luo, L. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports. 6:26608
Liu, C., Wu, C., Yang, Q., Gao, J., Li, L., Yang, D., Luo, L. (2016) Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction. Immunity. 44(5):1162-76
Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62
Shi, Y., Zhang, Y., Zhao, F., Ruan, H., Huang, H., Luo, L., Li, L. (2014) Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish. Scientific Reports. 4:5602
Yan, B., Han, P., Pan, L., Lu, W., Xiong, J., Zhang, M., Zhang, W., Li, L., Wen, Z. (2014) Il-1beta and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury-Induced Inflammation Model. Journal of immunology (Baltimore, Md. : 1950). 192(12):5998-6008
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W. (2013) Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish. Leukemia. 27(9):1913-7
Li, L., Yan, B., Shi, Y.Q., Zhang, W.Q., and Wen, Z.L. (2012) Live imaging reveals differing roles of macrophages and neutrophils during Zebrafish tail fin regeneration. The Journal of biological chemistry. 287(30):25353-25360
Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P.P., Zhang, M., Zhang, W., and Wen, Z. (2012) Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood. 119(22):5239-5249
Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101
Li, L., Jin, H., Xu, J., Shi, Y., and Wen, Z. (2011) Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood. 117(4):1359-1369