PUBLICATION
Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay
- Authors
- Dasari, B., Jogula, S., Borhade, R., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P.
- ID
- ZDB-PUB-130131-3
- Date
- 2013
- Source
- Organic letters 15(3): 432-435 (Journal)
- Registered Authors
- Kitambi, Satish Srinivas
- Keywords
- none
- MeSH Terms
-
- Angiogenesis Inhibitors/chemical synthesis*
- Angiogenesis Inhibitors/chemistry
- Angiogenesis Inhibitors/pharmacology
- Animals
- Carbohydrates/chemistry*
- Drug Design
- Macrocyclic Compounds/chemical synthesis*
- Macrocyclic Compounds/chemistry
- Macrocyclic Compounds/pharmacology
- Molecular Structure
- Zebrafish
- PubMed
- 23331160 Full text @ Org. Lett.
Citation
Dasari, B., Jogula, S., Borhade, R., Balasubramanian, S., Chandrasekar, G., Kitambi, S.S., and Arya, P. (2013) Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay. Organic letters. 15(3):432-435.
Abstract
A practical and modular approach to obtain a diverse set of 14-membered macrocyclic compounds from carbohydrates is developed that utilizes functional groups at C-1 and C-5. The evaluation of this toolbox in various zebrafish assays led to the identification of 2.7f as an antiangiogenesis agent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping