PUBLICATION

Zebrafish genetics gets the Scube on Hedgehog secretion

Authors
Ingham, P.W.
ID
ZDB-PUB-121205-8
Date
2012
Source
Genes & Development   26(22): 2468-2470 (Review)
Registered Authors
Ingham, Philip
Keywords
DispatchedA, Hedgehog, Scube2, morphogen release, palmitate
MeSH Terms
none
PubMed
23154980 Full text @ Genes & Dev.
Citation
Ingham, P.W. (2012) Zebrafish genetics gets the Scube on Hedgehog secretion. Genes & Development. 26(22):2468-2470.
Abstract

Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312?1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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