ZFIN ID: ZDB-PUB-120718-26
beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation
Mahabaleshwar, H., Tarbashevich, K., Nowak, M., Brand, M., and Raz, E.
Date: 2012
Source: Development (Cambridge, England)   139(16): 2897-2902 (Journal)
Registered Authors: Brand, Michael, Mahabaleshwar, Harsha, Nowak, Matthias, Raz, Erez, Tarbashevich, Katsiyarina
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Arrestins/antagonists & inhibitors
  • Arrestins/genetics
  • Arrestins/metabolism*
  • Cell Movement/physiology
  • Chemokine CXCL12/genetics
  • Chemokine CXCL12/metabolism
  • Endosomes/metabolism
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Germ Cells/cytology
  • Germ Cells/metabolism
  • Receptors, CXCR/genetics
  • Receptors, CXCR/metabolism*
  • Tissue Distribution
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/antagonists & inhibitors
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 22791893 Full text @ Development

A crucial regulator of Cxcl12 is the decoy receptor Cxcr7, which controls the level of the chemokine in the tissue. The molecular mechanisms that enable Cxcr7 to function as an efficient molecular sink are not known. Using zebrafish primordial germ cells as a model, we identify a novel role for β-arrestins in controlling the intracellular trafficking of Cxcr7. β-arrestins facilitate the recycling of Cxcr7 from late endosomal compartments back to the plasma membrane, whereas the internalized ligand undergoes lysosomal degradation. β-arrestins thus function in regulating chemokine gradient formation, allowing responding cells to discriminate between alternative migration targets in vivo.