ZFIN ID: ZDB-PUB-120630-7
Conserved Expression Signatures between Medaka and Human Pigment Cell Tumors
Schartl, M., Kneitz, S., Wilde, B., Wagner, T., Henkel, C.V., Spaink, H.P., and Meierjohann, S.
Date: 2012
Source: PLoS One 7(5): e37880 (Journal)
Registered Authors: Schartl, Manfred, Spaink, Herman P., Wagner, Toni
Keywords: none
MeSH Terms:
  • Animals
  • Cell Line, Tumor
  • Humans
  • MAP Kinase Signaling System/genetics
  • Melanoma/genetics*
  • Melanoma/pathology
  • Oryzias/genetics*
  • Skin Neoplasms/genetics
  • Skin Neoplasms/pathology
  • Transcriptome*
  • Uveal Neoplasms/genetics
  • Uveal Neoplasms/pathology
PubMed: 22693581 Full text @ PLoS One
ABSTRACT

Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massive parallel sequencing of different types of melanoma from medaka were generated and compared to microarray datasets from zebrafish and human melanoma. This revealed molecular conservation at various levels between fish models and human tumors providing a useful strategy for identifying expression signatures strongly associated with disease phenotypes and uncovering new melanoma molecules.

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