Yamazoe, S., Shestopalov, I.A., Provost, E., Leach, S.D., and Chen, J.K. (2012) Cyclic Caged Morpholinos: Conformationally Gated Probes of Embryonic Gene Function. Angewandte Chemie (International ed. in English). 51(28):6908-6911.
Feeling a bit cagey: Morpholino-based antisense reagents have been caged through oligonucleotide cyclization (see scheme), enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined.