ZFIN ID: ZDB-PUB-120608-2
Involvement of claudins in zebrafish brain ventricle morphogenesis
Zhang, J., Liss, M., Wolburg, H., Blasig, I.E., and Abdelilah-Seyfried, S.
Date: 2012
Source: Annals of the New York Academy of Sciences   1257(1): 193-198 (Review)
Registered Authors: Abdelilah-Seyfried, Salim
Keywords: brain ventricle morphogenesis, tight junction, claudin-5a, claudin-3
MeSH Terms:
  • Animals
  • Cerebral Ventricles/embryology*
  • Cerebral Ventricles/metabolism
  • Claudins/genetics
  • Claudins/metabolism*
  • Morphogenesis
  • Organogenesis
  • Phylogeny
  • Tight Junctions/metabolism*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
  • Zebrafish Proteins/metabolism*
PubMed: 22671606 Full text @ Ann N Y Acad Sci

Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow– and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial–ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood–brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.