PUBLICATION

Studying cellular and subcellular dynamics in the developing zebrafish nervous system

Authors
Hocking, J.C., Distel, M., and Köster, R.W.
ID
ZDB-PUB-120404-15
Date
2013
Source
Experimental neurology   242: 1-10 (Review)
Registered Authors
Distel, Martin, Hocking, Jennifer, Köster, Reinhard W.
Keywords
in vivo imaging, nucleokinesis, interkinetic nuclear migration, cell biology, centrosome, axonogenesis, combinatorial genetics, Gal4, Cre
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cell Division
  • Cell Movement
  • Green Fluorescent Proteins/genetics
  • Green Fluorescent Proteins/metabolism
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism
  • Nervous System*/cytology
  • Nervous System*/embryology
  • Nervous System*/growth & development
  • Neurogenesis
  • Neurons/cytology*
  • Neurons/physiology
  • Zebrafish*/anatomy & histology
  • Zebrafish*/embryology
  • Zebrafish*/growth & development
PubMed
22465266 Full text @ Exp. Neurol.
Abstract

Cells of the developing nervous system undergo incredible proliferation, migrate long distances, and differentiate morphologically into highly specialized structures. The dynamic changes happening at the cellular and subcellular levels can only be properly understood using time-lapse in vivo imaging approaches, for which the transparent embryonic zebrafish is ideally suited. Moreover, the genetic techniques adapted for zebrafish provide incredible spatial, temporal, and quantitative control over the expression of fluorescent proteins, such that practically any structure or cell of interest can be highlighted. Recent zebrafish studies provide new insights into the dynamic nature of cell division, neuronal migration and axon and dendrite formation, but form only the beginning of a promising new era of in vivo live imaging.

Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes