PUBLICATION
Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance
- Authors
- Jain, R.A., Wolman, M.A., Schmidt, L.A., Burgess, H.A., and Granato, M.
- ID
- ZDB-PUB-111114-20
- Date
- 2011
- Source
- PLoS One 6(10): e26510 (Journal)
- Registered Authors
- Burgess, Harold, Granato, Michael, Jain, Roshan, Wolman, Marc
- Keywords
- none
- MeSH Terms
-
- Animals
- Mutation*
- Phenotype
- Zebrafish/genetics*
- PubMed
- 22039502 Full text @ PLoS One
Citation
Jain, R.A., Wolman, M.A., Schmidt, L.A., Burgess, H.A., and Granato, M. (2011) Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance. PLoS One. 6(10):e26510.
Abstract
Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a ‘phenotyping by segregation’ strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable strategy to map zebrafish mutants with subtle phenotypes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping