PUBLICATION
Zebrafish models for cancer
- Authors
- Liu, S., and Leach, S.D.
- ID
- ZDB-PUB-110131-9
- Date
- 2011
- Source
- Annual review of pathology 6: 71-93 (Review)
- Registered Authors
- Leach, Steven D.
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Humans
- Neoplasms/genetics*
- Neoplasms/pathology*
- Neoplasms/physiopathology
- Zebrafish*
- PubMed
- 21261518 Full text @ Annu. Rev. Pathol.
Citation
Liu, S., and Leach, S.D. (2011) Zebrafish models for cancer. Annual review of pathology. 6:71-93.
Abstract
First established as a valuable vertebrate model system for studying development, zebrafish have emerged as an attractive animal system for modeling human cancers. Major technical advances have been essential for the generation of zebrafish cancer models relevant to human diseases. These models develop tumors in various organ sites that bear striking resemblance to human malignances, both histologically and genetically. Thus, the focus of cancer research in zebrafish has transcended the need to validate zebrafish as a viable model organism to study cancer biology. With the significant advantages of in vivo imaging, the power of forward genetics, well-established high efficiency for transgenesis, and ease of transplantation, further exploration of the zebrafish cancer models not only will generate unique insights into underlying mechanisms of cancer but will also provide platforms useful for drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping