ZFIN ID: ZDB-PUB-110103-4
Zebrafish models of the immune response: taking it on the ChIn
Renshaw, S.A., and Ingham, P.W.
Date: 2010
Source: BMC Biology   8(1): 148 (Other)
Registered Authors: Ingham, Philip, Renshaw, Steve A.
Keywords: none
MeSH Terms:
  • Animals
  • Immunity, Innate*
  • Inflammation/immunology
  • Models, Animal*
  • Zebrafish/immunology*
PubMed: 21176245 Full text @ BMC Biol.
The zebrafish is proving to be an extremely versatile new experimental model for unraveling the mysteries of innate immunity and has considerable promise as a system for the identification of novel modulators of this crucial biological process. A rate-limiting factor, however, is the mechanical stimulus required to induce the inflammatory response. A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field.