PUBLICATION
Zebrafish models of the immune response: taking it on the ChIn
- Authors
- Renshaw, S.A., and Ingham, P.W.
- ID
- ZDB-PUB-110103-4
- Date
- 2010
- Source
- BMC Biology 8(1): 148 (Other)
- Registered Authors
- Ingham, Philip, Renshaw, Steve A.
- Keywords
- none
- MeSH Terms
-
- Zebrafish/immunology*
- Inflammation/immunology
- Animals
- Models, Animal*
- Immunity, Innate*
- PubMed
- 21176245 Full text @ BMC Biol.
Citation
Renshaw, S.A., and Ingham, P.W. (2010) Zebrafish models of the immune response: taking it on the ChIn. BMC Biology. 8(1):148.
Abstract
The zebrafish is proving to be an extremely versatile new experimental model for unraveling the mysteries of innate immunity and has considerable promise as a system for the identification of novel modulators of this crucial biological process. A rate-limiting factor, however, is the mechanical stimulus required to induce the inflammatory response. A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping