PUBLICATION
A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages
- Authors
- Sheehan-Rooney, K., Pálinkášová, B., Eberhart, J.K., and Dixon, M.J.
- ID
- ZDB-PUB-101122-28
- Date
- 2010
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 239(12): 3481-3491 (Journal)
- Registered Authors
- Eberhart, Johann, Sheehan-Rooney, Kelly
- Keywords
- none
- MeSH Terms
-
- Animals
- Chick Embryo
- Chickens/metabolism
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology
- Haplorhini/embryology
- In Situ Hybridization
- Matrix Attachment Region Binding Proteins/genetics
- Matrix Attachment Region Binding Proteins/metabolism*
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors/genetics
- Transcription Factors/metabolism*
- Vertebrates/embryology*
- Zebrafish/embryology
- PubMed
- 21089028 Full text @ Dev. Dyn.
Citation
Sheehan-Rooney, K., Pálinkášová, B., Eberhart, J.K., and Dixon, M.J. (2010) A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3481-3491.
Abstract
Mutation of SATB2 causes cleft palate in humans. To understand the role of SATB2 function in palatogenesis, SATB2 analyses in vertebrate model systems will be essential. To facilitate these analyses, we have performed a cross-species comparison of SATB2 structure and function across three vertebrate model systems: mouse, chick, and zebrafish. We find that the SATB2 transcript is highly conserved across human, mouse, chick, and zebrafish, especially within the Satb2 functional domains. Furthermore, our expression analyses demonstrate that SATB2 is likely to have similar functions in vertebrate model organisms and humans during development of the facial processes and secondary palate. Together, these data suggest an evolutionary conserved role for SATB2 during development of the face and palate across vertebrates. Moreover, expression of zebrafish satb2 in the anterior neurocranium supports the utility of the anterior neurocranium as a simplified model of amniote palatogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping