ZFIN ID: ZDB-PUB-101018-15
The habenula is crucial for experience-dependent modification of fear responses in zebrafish
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
Date: 2010
Source: Nature Neuroscience 13(11): 1354-1356 (Journal)
Registered Authors: Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
Keywords: none
MeSH Terms: Adaptation, Physiological/physiology; Amino Acids/metabolism; Analysis of Variance; Animals; Animals, Genetically Modified (all 31) expand
PubMed: 20935642 Full text @ Nat. Neurosci.
FIGURES   (current status)
ABSTRACT
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
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