PUBLICATION

The habenula is crucial for experience-dependent modification of fear responses in zebrafish

Authors
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
ID
ZDB-PUB-101018-15
Date
2010
Source
Nature Neuroscience   13(11): 1354-1356 (Journal)
Registered Authors
Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
Keywords
none
MeSH Terms
  • RNA, Messenger/metabolism
  • Time Factors
  • Locomotion/physiology
  • Carbocyanines/metabolism
  • Gene Expression Regulation/physiology*
  • Amino Acids/metabolism
  • Adaptation, Physiological/physiology
  • HSP72 Heat-Shock Proteins/genetics
  • Neural Pathways/physiology
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Green Fluorescent Proteins/genetics
  • Animals, Genetically Modified
  • Behavior, Animal
  • Fear/physiology*
  • Conditioning, Classical/physiology
  • Electroshock/adverse effects
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • In Situ Nick-End Labeling
  • Larva
  • Animals
  • Tryptophan Hydroxylase/genetics
  • Tryptophan Hydroxylase/metabolism
  • Zebrafish/physiology*
  • Habenula/cytology
  • Habenula/metabolism
  • Habenula/physiology*
  • Transcription Factor Brn-3A/genetics
  • Neurons/metabolism
  • Analysis of Variance
PubMed
20935642 Full text @ Nat. Neurosci.
Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping