PUBLICATION
The habenula is crucial for experience-dependent modification of fear responses in zebrafish
- Authors
- Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
- ID
- ZDB-PUB-101018-15
- Date
- 2010
- Source
- Nature Neuroscience 13(11): 1354-1356 (Journal)
- Registered Authors
- Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
- Keywords
- none
- MeSH Terms
-
- Adaptation, Physiological/physiology
- RNA, Messenger/metabolism
- HSP72 Heat-Shock Proteins/genetics
- Carbocyanines/metabolism
- Time Factors
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Locomotion/physiology
- Electroshock/adverse effects
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Animals
- Fear/physiology*
- Neural Pathways/physiology
- Habenula/cytology
- Habenula/metabolism
- Habenula/physiology*
- Transcription Factor Brn-3A/genetics
- Analysis of Variance
- Larva
- In Situ Nick-End Labeling
- Green Fluorescent Proteins/genetics
- Neurons/metabolism
- Animals, Genetically Modified
- Gene Expression Regulation/physiology*
- Zebrafish/physiology*
- Tryptophan Hydroxylase/genetics
- Tryptophan Hydroxylase/metabolism
- Conditioning, Classical/physiology
- Amino Acids/metabolism
- Behavior, Animal
- PubMed
- 20935642 Full text @ Nat. Neurosci.
Citation
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H. (2010) The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nature Neuroscience. 13(11):1354-1356.
Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping