PUBLICATION
In vivo evidence for transdifferentiation of peripheral neurons
- Authors
- Wright, M.A., Mo, W., Nicolson, T., and Ribera, A.B.
- ID
- ZDB-PUB-100806-23
- Date
- 2010
- Source
- Development (Cambridge, England) 137(18): 3047-3056 (Journal)
- Registered Authors
- Mo, Weike, Nicolson, Teresa, Ribera, Angie, Wright, Melissa
- Keywords
- Dorsal root ganglia neurons, Transdifferentiation, Nav1.6, Zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Differentiation*
- Cell Movement
- Cell Transdifferentiation
- Ganglia, Spinal/cytology
- Ganglia, Spinal/embryology
- Ganglia, Spinal/metabolism
- Gene Expression Regulation, Developmental
- Mutation
- NAV1.6 Voltage-Gated Sodium Channel
- Neurons/cytology*
- Neurons/metabolism
- Sodium Channels/deficiency
- Sodium Channels/metabolism*
- Tyrosine 3-Monooxygenase/metabolism
- Zebrafish/growth & development*
- Zebrafish/metabolism
- Zebrafish Proteins/deficiency
- Zebrafish Proteins/metabolism*
- PubMed
- 20685733 Full text @ Development
Citation
Wright, M.A., Mo, W., Nicolson, T., and Ribera, A.B. (2010) In vivo evidence for transdifferentiation of peripheral neurons. Development (Cambridge, England). 137(18):3047-3056.
Abstract
It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish larvae that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa. Sodium channel knock-down promotes migration of differentiated sensory neurons away from the ganglia. Once in a new environment, sensory neurons transdifferentiate regardless of sodium channel expression. These findings reveal an unsuspected plasticity in differentiated neurons that points to new strategies for treatment of nervous system disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping