PUBLICATION
deLiver'in Regeneration: Injury Response and Development
- Authors
- Curado, S., and Stainier, D.Y.
- ID
- ZDB-PUB-100730-16
- Date
- 2010
- Source
- Seminars in liver disease 30(3): 288-295 (Review)
- Registered Authors
- Curado, Silvia, Stainier, Didier
- Keywords
- Hepatopathology, liver, damage, hepatocyte, biliary cell, oval cell, hepatectomy
- MeSH Terms
-
- Animals
- Cell Proliferation
- Cell Transdifferentiation
- Hepatectomy
- Humans
- Liver/metabolism
- Liver/pathology
- Liver/physiopathology*
- Liver/surgery
- Liver Diseases/metabolism
- Liver Diseases/pathology
- Liver Diseases/physiopathology*
- Liver Diseases/therapy
- Liver Regeneration*
- Mice
- Models, Animal
- Signal Transduction
- Zebrafish
- PubMed
- 20665380 Full text @ Semin. Liver Dis.
Citation
Curado, S., and Stainier, D.Y. (2010) deLiver'in Regeneration: Injury Response and Development. Seminars in liver disease. 30(3):288-295.
Abstract
Liver regeneration has traditionally been investigated in mammalian models. Recent technological developments in mouse genetics have greatly enhanced the resolving power of these studies. In addition, the zebrafish system has emerged as a complementary genetic system to study liver regeneration. One of the most promising attributes of the zebrafish system is its amenability to large-scale screens including genetic and chemical screens. Also, as our understanding of liver development is becoming more detailed, it is important to evaluate the commonalities and differences between organ development and regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping