PUBLICATION

Claudin-5a in developing zebrafish brain barriers: another brick in the wall

Authors
Abdelilah-Seyfried, S.
ID
ZDB-PUB-100726-19
Date
2010
Source
BioEssays : news and reviews in molecular, cellular and developmental biology   32(9): 768-776 (Review)
Registered Authors
Abdelilah-Seyfried, Salim
Keywords
blood brain barrier, Claudin-5, development, tight junctions, zebrafish
MeSH Terms
  • Animals
  • Blood-Brain Barrier/embryology*
  • Blood-Brain Barrier/metabolism
  • Blood-Brain Barrier/physiology
  • Cerebral Ventricles/physiology
  • Claudin-5
  • Claudins/metabolism*
  • Humans
  • Membrane Proteins/metabolism*
  • Neuroepithelial Cells/metabolism
  • Neuroepithelial Cells/physiology
  • Permeability
  • Protein Processing, Post-Translational*
  • Tight Junctions/genetics*
  • Tight Junctions/metabolism
  • Tight Junctions/physiology
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish/physiology
  • Zebrafish Proteins/metabolism*
PubMed
20652895 Full text @ Bioessays
Abstract
Claudins serve essential roles in regulating paracellular permeability properties within occluding junctions. Recent studies have begun to elucidate developmental roles of claudins within immature tissues. This work has uncovered an involvement of several claudins in determining tight junction properties that have an effect on embryonic morphogenesis and physiology. During zebrafish brain morphogenesis, Claudin-5a determines the paracellular permeability of tight junctions within a transient neuroepithelial-ventricular barrier that maintains the hydrostatic fluid pressure required for brain ventricular lumen expansion. However, the roles of Claudins in development may well extend beyond being mere junctional components. Several post-translational modifications of Claudins have been characterized that indicate a direct regulation by developmental signals. This review focuses on the involvement of Claudin-5a in cerebral barrier formation in the zebrafish embryo and includes some speculations about possible modes of regulation.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes