PUBLICATION
Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes
- Authors
- Mathur, P., and Guo, S.
- ID
- ZDB-PUB-100525-16
- Date
- 2010
- Source
- Neurobiology of disease 40(1): 66-72 (Review)
- Registered Authors
- Guo, Su, Mathur, Priya
- Keywords
- Zebrafish, Addiction, Anxiety, Schizophrenia, Autism
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Disease Models, Animal
- Genetic Predisposition to Disease/genetics*
- Humans
- Models, Genetic*
- Substance-Related Disorders/genetics*
- Substance-Related Disorders/metabolism
- Substance-Related Disorders/psychology*
- Zebrafish/genetics*
- PubMed
- 20493262 Full text @ Neurobiol. Dis.
Citation
Mathur, P., and Guo, S. (2010) Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiology of disease. 40(1):66-72.
Abstract
Despite massive research efforts the exact pathogenesis and pathophysiology of addiction and neuropsychiatric disorders such as anxiety, schizophrenia and autism remains largely unknown. Animal models can serve as tools to understand the etiology and pathogenesis of these disorders. In recent years researchers are turning to zebrafish as it allows easy access to all developmental stages and imaging of pathological processes as well as automated behavioral quantification coupled with large scale screening and mutagenesis strategies. This review summarizes studies conducted over the last few years which demonstrate the relevance of the zebrafish model to human diseases including addiction and neuropsychiatric disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping