Models of congenital deafness: Mouse and zebrafish
- Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M.
- Drug discovery today 2(2): 85-92 (Review)
- Registered Authors
- Whitfield, Tanya T.
- MeSH Terms
- none Full text @ Drug Discov. Today
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M. (2005) Models of congenital deafness: Mouse and zebrafish. Drug discovery today. 2(2):85-92.
Much of our understanding of the molecular mechanisms underlying hearing and deafness has come through the study of vertebrate model organisms. We review here the advantages and disadvantages of the mouse and the zebrafish as genetic model systems for hearing research. Despite anatomical differences, many of the key molecules required for hair cell development and function are highly conserved between the two species and both provide complementary approaches for the development of drugs to treat diseases of the ear.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes