PUBLICATION

Models of congenital deafness: Mouse and zebrafish

Authors
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M.
ID
ZDB-PUB-100323-1
Date
2005
Source
Drug discovery today   2(2): 85-92 (Review)
Registered Authors
Whitfield, Tanya T.
Keywords
none
MeSH Terms
none
PubMed
none Full text @ Drug Discov. Today
Abstract
Much of our understanding of the molecular mechanisms underlying hearing and deafness has come through the study of vertebrate model organisms. We review here the advantages and disadvantages of the mouse and the zebrafish as genetic model systems for hearing research. Despite anatomical differences, many of the key molecules required for hair cell development and function are highly conserved between the two species and both provide complementary approaches for the development of drugs to treat diseases of the ear.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes