ZFIN ID: ZDB-PUB-100323-1
Models of congenital deafness: Mouse and zebrafish
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M.
Date: 2005
Source: Drug discovery today   2(2): 85-92 (Review)
Registered Authors: Whitfield, Tanya T.
Keywords: none
MeSH Terms: none
PubMed: none Full text @ Drug Discov. Today
Much of our understanding of the molecular mechanisms underlying hearing and deafness has come through the study of vertebrate model organisms. We review here the advantages and disadvantages of the mouse and the zebrafish as genetic model systems for hearing research. Despite anatomical differences, many of the key molecules required for hair cell development and function are highly conserved between the two species and both provide complementary approaches for the development of drugs to treat diseases of the ear.