ZFIN ID: ZDB-PUB-100223-53
Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish
Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M.
Date: 2010
Source: Developmental Biology   340(2): 583-594 (Journal)
Registered Authors: Ghysen, Alain, Higashijima, Shin-ichi, Kawakami, Koichi, Wada, Hironori
Keywords: Lateral line, Neuromast, Postembryonic development, Dermal bone, Opercle, scale, Zebrafish, Medaka
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Body Patterning*
  • Bone and Bones/embryology
  • Dermis/cytology
  • Dermis/growth & development
  • Embryo, Nonmammalian
  • Immunohistochemistry
  • In Situ Hybridization
  • Lateral Line System/cytology
  • Lateral Line System/growth & development*
  • Mechanoreceptors/cytology
  • Microinjections
  • Microscopy, Video
  • Models, Biological
  • Morphogenesis*
  • Oligonucleotides, Antisense/metabolism
  • Oryzias/embryology
  • Oryzias/growth & development*
  • Species Specificity
  • Zebrafish/embryology
  • Zebrafish/growth & development*
PubMed: 20171200 Full text @ Dev. Biol.
The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic development in zebrafish. We also show that accessory neuromast formation is highly correlated to the development of underlying dermal structures such as bones and scales. Abnormalities in opercular bone morphogenesis, in endothelin 1-knockdown embryos, is accompanied by stereotypic errors in neuromast budding and positioning, further demonstrating the tight correlation between the patterning of neuromasts and of the underlying dermal bones. In medaka, where scales form between peridermis and opercular bones, the lateral line displays a scale-specific pattern which is never observed in zebrafish. These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns.