PUBLICATION
Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish
- Authors
- Lindeman, R.E., and Pelegri, F.
- ID
- ZDB-PUB-091120-49
- Date
- 2010
- Source
- Molecular reproduction and development 77(4): 299-313 (Review)
- Registered Authors
- Pelegri, Francisco
- Keywords
- none
- MeSH Terms
-
- Gene Expression Regulation, Developmental*
- Chromosome Segregation
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics*
- Zebrafish/physiology
- Centrosome/metabolism
- Embryonic Development/physiology*
- Cytoskeleton/metabolism
- Cell Cycle/physiology
- Fertilization/physiology*
- Embryo, Nonmammalian*/cytology
- Embryo, Nonmammalian*/physiology
- Animals
- Humans
- Germ Cells*/cytology
- Germ Cells*/physiology
- PubMed
- 19908256 Full text @ Mol. Reprod. Dev.
Citation
Lindeman, R.E., and Pelegri, F. (2010) Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish. Molecular reproduction and development. 77(4):299-313.
Abstract
In the earliest stages of animal development prior to the commencement of zygotic transcription, all critical cellular processes are carried out by maternally-provided molecular products accumulated in the egg during oogenesis. Disruption of these maternal products can lead to defective embryogenesis. In this review, we focus on maternal genes with roles in the fundamental processes of fertilization, cell division, centrosome regulation, and germ cell development with emphasis on findings from the zebrafish, as this is a unique and valuable model system for vertebrate reproduction.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping