PUBLICATION
Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
- Authors
- Dahl Ejby Jensen, L., Cao, R., Hedlund, E.M., Söll, I., Lundberg, J.O., Hauptmann, G., Steffensen, J.F., and Cao, Y.
- ID
- ZDB-PUB-091023-36
- Date
- 2009
- Source
- Proceedings of the National Academy of Sciences of the United States of America 106(43): 18408-18413 (Journal)
- Registered Authors
- Hauptmann, Giselbert, Söll, Iris
- Keywords
- blood vessel, lymphatic vessel
- MeSH Terms
-
- Aging
- Animals
- Arteries/metabolism*
- Catfishes/metabolism*
- Hypoxia/metabolism*
- Lymphatic Vessels/metabolism*
- Nitric Oxide/metabolism*
- Perfusion
- Zebrafish/metabolism*
- PubMed
- 19822749 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Dahl Ejby Jensen, L., Cao, R., Hedlund, E.M., Söll, I., Lundberg, J.O., Hauptmann, G., Steffensen, J.F., and Cao, Y. (2009) Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish. Proceedings of the National Academy of Sciences of the United States of America. 106(43):18408-18413.
Abstract
The blood and lymphatic vasculatures are structurally and functionally coupled in controlling tissue perfusion, extracellular interstitial fluids, and immune surveillance. Little is known, however, about the molecular mechanisms that underlie the regulation of bloodlymphatic vessel connections and lymphatic perfusion. Here we show in the adult zebrafish and glass catfish (Kryptopterus bicirrhis) that blood-lymphatic conduits directly connect arterial vessels to the lymphatic system. Under hypoxic conditions, arterial-lymphatic conduits (ALCs) became highly dilated and linearized by NO-induced vascular relaxation, which led to blood perfusion into the lymphatic system. NO blockage almost completely abrogated hypoxia-induced ALC relaxation and lymphatic perfusion. These findings uncover mechanisms underlying hypoxia-induced oxygen compensation by perfusion of existing lymphatics in fish. Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping