|ZFIN ID: ZDB-PUB-090914-42|
Convergence and extension movements during vertebrate gastrulation
Yin, C., Ciruna, B., and Solnica-Krezel, L.
|Source:||Current topics in developmental biology 89: 163-192 (Review)|
|Registered Authors:||Ciruna, Brian, Solnica-Krezel, Lilianna, Yin, Chunyue|
|Keywords:||Bmp, Directed migration, G protein, Intercalation, Mesoderm, Noncanonical Wnt signalling, Oriented cell division, Planar cell polarity, Stat3, Zebrafish|
|PubMed:||19737646 Full text @ Curr. Top. Dev. Biol.|
Yin, C., Ciruna, B., and Solnica-Krezel, L. (2009) Convergence and extension movements during vertebrate gastrulation. Current topics in developmental biology. 89:163-192.
ABSTRACTDuring vertebrate gastrulation, coordinated cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. The rates of C&E movements differ significantly according to the position and the stage of gastrulation. Here, we review the distinct cellular behaviors that define the spatial and temporal patterns of C&E movements, with the special emphasis on zebrafish. We also summarize the molecular regulation of these cellular behaviors and the interplay between different signaling pathways that drive C&E. Finally, to ensure efficient C&E movements, cells must achieve mediolaterally-elongated cell morphology and polarize motile protrusions. We discuss the recent discoveries on the molecular and cellular mechanisms by which the mediolateral cell polarity is established.
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