|ZFIN ID: ZDB-PUB-090422-4|
Calcium signaling in vertebrate embryonic patterning and morphogenesis
Slusarski, D.C., and Pelegri, F.
|Source:||Developmental Biology 307(1): 1-13 (Review)|
|Registered Authors:||Pelegri, Francisco, Slusarski, Diane C.|
|PubMed:||17531967 Full text @ Dev. Biol.|
Slusarski, D.C., and Pelegri, F. (2007) Calcium signaling in vertebrate embryonic patterning and morphogenesis. Developmental Biology. 307(1):1-13.
ABSTRACTSignaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.
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