ZFIN ID: ZDB-PUB-090422-4
Calcium signaling in vertebrate embryonic patterning and morphogenesis
Slusarski, D.C., and Pelegri, F.
Date: 2007
Source: Developmental Biology   307(1): 1-13 (Review)
Registered Authors: Pelegri, Francisco, Slusarski, Diane C.
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning*
  • Calcium Signaling/physiology*
  • Humans
  • Morphogenesis*
  • Organizers, Embryonic/cytology
  • Stem Cells/cytology
  • Stem Cells/physiology
  • Vertebrates
  • Wnt Proteins/metabolism
PubMed: 17531967 Full text @ Dev. Biol.
Signaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.