ZFIN ID: ZDB-PUB-080622-12
Modeling cardiovascular disease in the zebrafish
Chico, T.J., Ingham, P.W., and Crossman, D.C.
Date: 2008
Source: Trends in cardiovascular medicine   18(4): 150-155 (Review)
Registered Authors: Chico, Tim J., Ingham, Philip
Keywords: none
MeSH Terms:
  • Animals
  • Biomedical Research*/methods
  • Cardiovascular Diseases/genetics
  • Cardiovascular Diseases/pathology
  • Cardiovascular Diseases/physiopathology*
  • Cardiovascular System/embryology
  • Cardiovascular System/physiopathology
  • Disease Models, Animal
  • Drug Evaluation, Preclinical*/methods
  • Molecular Probe Techniques
  • Zebrafish*/embryology
  • Zebrafish*/genetics
  • Zebrafish Proteins/genetics
PubMed: 18555188 Full text @ Trends Cardiovasc. Med.
The zebrafish possesses a host of advantages that have established it as an excellent model of vertebrate development. These include ease of genetic manipulation and transgenesis, optical clarity, and small size and cost. Biomedical researchers are increasingly exploiting these advantages to model human disease mechanisms. Here we review the use of the zebrafish for cardiovascular research. We summarize previous studies with the use of this organism to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, and cardiac regeneration, evaluate its promise for novel drug discovery, and consider where the zebrafish fits into the framework of existing cardiovascular models.