PUBLICATION
Zebrafish as a new animal model for movement disorders
- Authors
- Flinn, L., Bretaud, S., Lo, C., Ingham, P.W., and Bandmann, O.
- ID
- ZDB-PUB-080512-8
- Date
- 2008
- Source
- Journal of neurochemistry 106(5): 1991-1997 (Review)
- Registered Authors
- Bandmann, Oliver, Ingham, Philip
- Keywords
- none
- MeSH Terms
-
- Animals
- Movement Disorders/drug therapy
- Movement Disorders/genetics*
- Movement Disorders/physiopathology
- Genetic Predisposition to Disease/genetics
- Antiparkinson Agents/pharmacology*
- Zebrafish/genetics*
- Zebrafish/metabolism
- Mutation/genetics
- Parkinson Disease/drug therapy
- Parkinson Disease/genetics*
- Parkinson Disease/physiopathology
- Disease Models, Animal*
- Drug Evaluation, Preclinical
- Huntington Disease/drug therapy
- Huntington Disease/genetics*
- Huntington Disease/physiopathology
- PubMed
- 18466340 Full text @ J. Neurochem.
Citation
Flinn, L., Bretaud, S., Lo, C., Ingham, P.W., and Bandmann, O. (2008) Zebrafish as a new animal model for movement disorders. Journal of neurochemistry. 106(5):1991-1997.
Abstract
The zebrafish, long recognised as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high-throughput in vivo drug screening.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping