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ZFIN ID: ZDB-PUB-071210-16
Insertional mutagenesis strategies in zebrafish
Sivasubbu, S., Balciunas, D., Amsterdam, A.,and Ekker, S.C.
Date: 2007
Source: Genome biology   8(1): S9 (Review)
Registered Authors: Amsterdam, Adam, Balciunas, Darius, Ekker, Stephen C., Sivasubbu, Sridhar
Keywords: none
MeSH Terms:
  • Animals
  • DNA Transposable Elements
  • Embryonic Stem Cells/metabolism
  • Mutagenesis, Insertional/methods*
  • Retroviridae
  • Zebrafish/genetics*
  • Zebrafish/virology
PubMed: 18047701 Full text @ Genome Biol.
We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mechanisms and concepts of new transposon-based mutagenesis approaches under development, including prospects for conditional 'gene trapping' and 'gene breaking' approaches.