PUBLICATION
Maternal nodal and zebrafish embryogenesis
- Authors
- Bennett, J.T., Stickney, H.L., Choi, W.Y., Ciruna, B., Talbot, W.S., and Schier, A.F.
- ID
- ZDB-PUB-071118-29
- Date
- 2007
- Source
- Nature 450(7167): E1-E4 (Journal)
- Registered Authors
- Bennett, Jimmy, Choi, Wen-Yee, Ciruna, Brian, Schier, Alexander, Stickney, Heather, Talbot, William S.
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning*
- Embryo, Nonmammalian/metabolism
- Female
- Intracellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/metabolism*
- Models, Biological
- Mothers
- Nodal Signaling Ligands
- Ovary/metabolism
- Ovum/metabolism
- RNA Splicing
- Reproducibility of Results
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 17994032 Full text @ Nature
Citation
Bennett, J.T., Stickney, H.L., Choi, W.Y., Ciruna, B., Talbot, W.S., and Schier, A.F. (2007) Maternal nodal and zebrafish embryogenesis. Nature. 450(7167):E1-E4.
Abstract
In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway. Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping