ZFIN ID: ZDB-PUB-071118-29
Maternal nodal and zebrafish embryogenesis
Bennett, J.T., Stickney, H.L., Choi, W.Y., Ciruna, B., Talbot, W.S., and Schier, A.F.
Date: 2007
Source: Nature   450(7167): E1-E4 (Journal)
Registered Authors: Bennett, Jimmy, Choi, Wen-Yee, Ciruna, Brian, Schier, Alexander, Stickney, Heather, Talbot, William S.
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning*
  • Embryo, Nonmammalian/metabolism
  • Female
  • Intracellular Signaling Peptides and Proteins/genetics
  • Intracellular Signaling Peptides and Proteins/metabolism*
  • Models, Biological
  • Mothers
  • Nodal Signaling Ligands
  • Ovary/metabolism
  • Ovum/metabolism
  • RNA Splicing
  • Reproducibility of Results
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 17994032 Full text @ Nature
In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway. Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.