PUBLICATION

Axial patterning in the developing vertebrate inner ear

Authors
Whitfield, T.T., and Hammond, K.L.
ID
ZDB-PUB-071001-8
Date
2007
Source
The International journal of developmental biology   51(6-7): 507-520 (Journal)
Registered Authors
Hammond, Katherine L., Whitfield, Tanya T.
Keywords
axis, inner ear, otic vesicle, otocyst, axial patterning
MeSH Terms
  • Animals
  • Body Patterning*
  • Ear, Inner/embryology*
  • Embryo, Mammalian/metabolism
  • Embryo, Nonmammalian/metabolism
  • Embryonic Induction
  • Gene Expression Regulation, Developmental
  • Hedgehog Proteins/metabolism
  • Models, Biological
  • Morphogenesis
  • Rhombencephalon/metabolism
  • Rhombencephalon/physiology
  • Signal Transduction
  • Vertebrates/embryology*
  • Wnt Proteins/metabolism
PubMed
17891713 Full text @ Int. J. Dev. Biol.
Abstract
Axial patterning in the vertebrate inner ear has been studied for over eighty years, and recent work has made great progress towards an understanding of the molecular mechanisms responsible for establishing asymmetries about the otic axes. Tissues extrinsic to the ear provide sources of signalling molecules that are active early in development, at or before otic placode stages, while intrinsic factors interpret these signals to establish and maintain axial pattern. Key features of dorsoventral otic patterning in amniote embryos involve Wnt and Fgf signalling from the hindbrain and Hh signalling from midline tissues (notochord and floorplate). Mutual antagonism between these pathways and their downstream targets within the otic epithelium help to refine and maintain dorsoventral axial patterning in the ear. In the zebrafish ear, the same tissues and signals are implicated, but appear to play a role in anteroposterior, rather than dorsoventral, otic patterning. Despite this paradox, conservation of mechanisms may be higher than is at first apparent.
Genes / Markers
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Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes