PUBLICATION
Conserved mechanisms regulate outgrowth in zebrafish fins
- Authors
- Iovine, M.K.
- ID
- ZDB-PUB-070920-28
- Date
- 2007
- Source
- Nature Chemical Biology 3(10): 613-618 (Review)
- Registered Authors
- Iovine, M. Kathryn
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics
- Body Patterning/physiology
- Bone Development/genetics
- Bone Development/physiology
- Embryonic Induction/genetics
- Embryonic Induction/physiology*
- Extremities/embryology
- Extremities/physiology*
- Gene Expression Regulation/genetics
- Gene Expression Regulation/physiology
- Invertebrates
- Morphogenesis/genetics
- Morphogenesis/physiology*
- Mutation
- Regeneration/genetics
- Regeneration/physiology*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/growth & development*
- PubMed
- 17876318 Full text @ Nat. Chem. Biol.
Citation
Iovine, M.K. (2007) Conserved mechanisms regulate outgrowth in zebrafish fins. Nature Chemical Biology. 3(10):613-618.
Abstract
Regulation of size is one of the fundamental problems in biology. One general strategy has been to identify molecules required for cell growth and cell proliferation within an organ. This has been particularly revealing, identifying cell-autonomous pathways involved in cell growth, survival and proliferation. In order to identify pathways regulating overall limb growth and morphology, experiments have evaluated gene expression, transplanted and removed tissues, and knocked out genes. This work has provided a vast amount of information identifying molecular mechanisms regulating limb axis formation, outgrowth, and pattern formation. Using the zebrafish fin, genetic, cellular and molecular strategies have also been employed to follow both normal patterns of fin growth and growth in fin mutants. This review will focus on cellular and molecular regulation of the outgrowth and patterning of the zebrafish caudal fin during regeneration, and will emphasize similarities to other systems. Future perspectives describe opportunities using the zebrafish fin to reveal mechanisms underlying the regulation of final size.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping