ZFIN ID: ZDB-PERS-000428-9
Iovine, M. Kathryn
Email: mki3@lehigh.edu
URL: http://www.lehigh.edu/~inbios/fisharecool.html
Affiliation: Iovine Lab
Address: Department of Biological Sciences Lehigh University B-217 Iacocca Hall 111 Research Drive Bethlehem, PA 18015 USA
Country: United States
Phone: (610) 758-6981
Fax: (610) 758-4004

My lab is interested in how coordinated growth of the body and fins is established and maintained.

Bhattacharya, S., Hyland, C., Falk, M.M., Iovine, M.K. (2020) Connexin43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development (Cambridge, England). 147(13):
Bhattacharya, S., Gargiulo, D., Iovine, M.K. (2018) Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43. Development (Cambridge, England). 145(23):
Banerji, R., Skibbens, R.V., Iovine, M.K. (2017) How many roads lead to cohesinopathies?. Developmental dynamics : an official publication of the American Association of Anatomists. 246(11):881-888
Banerji, R., Skibbens, R.V., Iovine, M.K. (2017) Cohesin mediates Esco2-dependent transcriptional regulation in zebrafish regenerating fin model of Roberts syndrome. Biology Open. 6(12):1802-1813
Farwell, S.L.N., Reylander, K.G., Iovine, M.K., Lowe-Krentz, L.J. (2017) Novel Heparin Receptor Transmembrane Protein 184a Regulates Angiogenesis in the Adult Zebrafish Caudal Fin. Frontiers in Physiology. 8:671
Dardis, G., Tryon, R., Ton, Q., Johnson, S.L., Iovine, M.K. (2017) Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. Developmental dynamics : an official publication of the American Association of Anatomists. 246(9):691-699
Barton, R., Khakbaz, P., Bera, I., Klauda, J.B., Iovine, M.K., Berger, B.W. (2016) Interplay of specific trans- and juxtamembrane interfaces in Plexin A3 dimerization and signal transduction. Biochemistry. 55(35):4928-38
Holtzman, N.G., Iovine, M.K., Liang, J.O., Morris, J. (2016) Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio. Genetics. 203:1069-1089
Misu, A., Yamanaka, H., Aramaki, T., Kondo, S., Skerrett, I.M., Iovine, M.K., Watanabe, M. (2016) Two different functions of Connexin43 confer two different bone phenotypes in zebrafish. The Journal of biological chemistry. 291(24):12601-11
Govindan, J., Tun, K.M., Iovine, M.K. (2016) Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS One. 11:e0148202
Banerji, R., Eble, D.M., Iovine, M.K., Skibbens, R.V. (2016) Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin. Developmental dynamics : an official publication of the American Association of Anatomists. 245(1):7-21
Bhadra, J., Iovine, M.K. (2015) Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin. Mechanisms of Development. 138 Pt 3:364-74
Govindan, J., Iovine, M.K. (2015) Dynamic remodeling of the extra cellular matrix during zebrafish fin regeneration. Gene expression patterns : GEP. 19(1-2):21-9
Barton, R., Driscoll, A., Flores, S., Mudbhari, D., Collins, T., Iovine, M.K., Berger, B.W. (2015) Cysteines in the neuropilin-2 MAM domain modulate receptor homooligomerization and signal transduction. Biopolymers. 104(4):371-8
Barton, R., Palacio, D., Iovine, M.K., Berger, B.W. (2015) A Cytosolic Juxtamembrane Interface Modulates Plexin A3 Oligomerization and Signal Transduction. PLoS One. 10:e0116368
Govindan, J., and Iovine, M.K. (2014) Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton. PLoS One. 9(2):e88574
Ton, Q.V., and Iovine, M.K. (2013) Identification of an evx1-Dependent Joint-Formation Pathway during FIN Regeneration. PLoS One. 8(11):e81240
Ton, Q.V., and Iovine, M.K. (2012) Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration. Developmental Biology. 366(2):195-203
Gerhart, S.V., Eble, D.M., Burger, R.M., Oline, S.N., Vacaru, A., Sadler, K.C., Jefferis, R., and Iovine, M.K. (2012) The Cx43-like Connexin Protein Cx40.8 Is Differentially Localized during Fin Ontogeny and Fin Regeneration. PLoS One. 7(2):e31364
Gerhart, S.V., Jefferis, R., and Iovine, M.K. (2009) Cx40.8, a Cx43-like protein, forms gap junction channels inefficiently and may require Cx43 for its association at the plasma membrane. FEBS letters. 583(21):3419-3424
Brown, A.M., Fisher, S., and Iovine, M.K. (2009) Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(11):2922-2928
Sims Jr, K., Eble, D.M., and Iovine, M.K. (2009) Connexin43 regulates joint location in zebrafish fins. Developmental Biology. 327(2):410-418
Gumm, J.M., Snekser, J.L., and Iovine, M.K. (2009) Fin-mutant female zebrafish (Danio rerio) exhibit differences in association preferences for male fin length. Behavioural processes. 80(1):35-38
Hoptak-Solga, A.D., Nielsen, S., Jain, I., Thummel, R., Hyde, D.R., and Iovine, M.K. (2008) Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology. 317(2):541-548
Iovine, M.K., Gumpert, A.M., Falk, M.M., and Mendelson, T.C. (2008) Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS letters. 582(2):165-170
Iovine, M.K. (2007) Conserved mechanisms regulate outgrowth in zebrafish fins. Nature Chemical Biology. 3(10):613-618
Jain, I., Stroka, C., Yan, J., Huang, W.M., and Iovine, M.K. (2007) Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Developmental dynamics : an official publication of the American Association of Anatomists. 236(9):2668-2674
Hoptak-Solga, A.D., Klein, K.A., Derosa, A.M., White, T.W., and Iovine, M.K. (2007) Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communication. FEBS letters. 581(17):3297-3302
Itzkowitz, M., and Iovine, M.K. (2007) Single gene mutations causing exaggerated fins also cause non-genetic changes in the display behavior of male zebrafish. Behaviour. 144(7):787-795
Goldsmith, M.I., Iovine, M.K., O'reilly-Pol, T., and Johnson, S.L. (2006) A developmental transition in growth control during zebrafish caudal fin development. Developmental Biology. 296(2):450-457
Eastman, S.D., Chen, T.H., Falk, M.M., Mendelson, T.C., and Iovine, M.K. (2006) Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 87(2):265-274
Iovine, M.K., Higgins, E.P., Hindes, A., Coblitz, B., and Johnson, S.L. (2005) Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Developmental Biology. 278(1):208-219
Iovine, M.K., and Johnson, S.L. (2002) A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Genomics. 79(6):756-759
Iovine, M.K. and Johnson, S.L. (2000) Genetic analysis of isometric growth control mechanisms in the zebrafish caudal fin. Genetics. 155(3):1321-1329

Iovine, M.K. and Wente, S.R. (1997) A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. J. Cell Biol. 137(4):797-811.

Iovine, M.K., Watkins, J.L. and Wente, S.R. (1995) The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor. J. Cell Biol. 131(6 Pt. 2):1699-1713.