PUBLICATION

Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis

Authors
Ryu, S., and Driever, W.
ID
ZDB-PUB-070523-1
Date
2006
Source
Cell cycle (Georgetown, Tex.)   5(11): 1140-1142 (Journal)
Registered Authors
Driever, Wolfgang, Ryu, Soojin
Keywords
MCM, zebrafish, proliferation zones, stem cells, embryogenesis
MeSH Terms
  • Animals
  • Biomarkers/analysis
  • Cell Cycle Proteins/analysis*
  • Cell Proliferation*
  • DNA Replication
  • Embryo, Nonmammalian
  • Embryonic Development*
  • Zebrafish
PubMed
16721065 Full text @ Cell Cycle
Abstract
Regulation of cell proliferation is of fundamental importance for growth and prevention of cancer. An obligatory step in the regulation of cell proliferation is the control of the initiation of DNA synthesis. The minichromosome maintenance (MCM) proteins are essential DNA replication factors crucial for initiating DNA synthesis once every cell cycle. Recent studies show that the level of MCM proteins is stringently regulated to correlate with cell proliferation and carcinogenesis. Here we discuss recent data, which highlights the usefulness of minichromosome maintenance (MCM) gene expression for detecting proliferating cells as well as zones containing proliferative/stem cells during embryogenesis in a whole organism.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping