PUBLICATION
Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis
- Authors
- Ryu, S., and Driever, W.
- ID
- ZDB-PUB-070523-1
- Date
- 2006
- Source
- Cell cycle (Georgetown, Tex.) 5(11): 1140-1142 (Journal)
- Registered Authors
- Driever, Wolfgang, Ryu, Soojin
- Keywords
- MCM, zebrafish, proliferation zones, stem cells, embryogenesis
- MeSH Terms
-
- Animals
- Zebrafish
- Biomarkers/analysis
- Cell Proliferation*
- DNA Replication
- Embryonic Development*
- Embryo, Nonmammalian
- Cell Cycle Proteins/analysis*
- PubMed
- 16721065 Full text @ Cell Cycle
Citation
Ryu, S., and Driever, W. (2006) Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis. Cell cycle (Georgetown, Tex.). 5(11):1140-1142.
Abstract
Regulation of cell proliferation is of fundamental importance for growth and prevention of cancer. An obligatory step in the regulation of cell proliferation is the control of the initiation of DNA synthesis. The minichromosome maintenance (MCM) proteins are essential DNA replication factors crucial for initiating DNA synthesis once every cell cycle. Recent studies show that the level of MCM proteins is stringently regulated to correlate with cell proliferation and carcinogenesis. Here we discuss recent data, which highlights the usefulness of minichromosome maintenance (MCM) gene expression for detecting proliferating cells as well as zones containing proliferative/stem cells during embryogenesis in a whole organism.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping