ZFIN ID: ZDB-PUB-070330-29
The zebrafish retinoid-related orphan receptor (ror) gene family
Flores, M.V., Hall, C., Jury, A., Crosier, K., and Crosier, P.
Date: 2007
Source: Gene expression patterns : GEP   7(5): 535-543 (Journal)
Registered Authors: Crosier, Kathy, Crosier, Phil, Flores, Maria, Hall, Chris
Keywords: Rora, Rorb, Rorc, Retinoid-related orphan receptors, Phylogeny, Synteny, Zebrafish, Pineal gland, Retina, Gut, Maternal transcript
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Molecular Sequence Data
  • Nuclear Receptor Subfamily 1, Group F, Member 2
  • RNA Probes
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Receptors, Cytoplasmic and Nuclear/genetics*
  • Receptors, Cytoplasmic and Nuclear/metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed: 17374568 Full text @ Gene Expr. Patterns
The retinoid-related orphan receptors Rora, b and c are highly conserved transcription factors belonging to the steroid hormone receptor superfamily. Mammalian ROR proteins perform key regulatory roles in a number of processes during embryonic development and in the adult including neurogenesis, bone metabolism and modulation of circadian rhythms. A more recent area of interest has been their roles in the development and function of the immune system. In particular, RORA has been implicated in the regulation of inflammatory cytokine production, and RORC has been shown to be essential in the development of the T lymphocyte repertoire and of secondary lymphoid organs. We cloned the zebrafish orthologs for the Ror gene family. Assignment of orthologies was supported by analysis of the phylogenetic relationships between zebrafish and other vertebrate Ror genes based on sequence similarities, and conserved syntenies with the human Ror gene loci.