PUBLICATION
The zebrafish retinoid-related orphan receptor (ror) gene family
- Authors
- Flores, M.V., Hall, C., Jury, A., Crosier, K., and Crosier, P.
- ID
- ZDB-PUB-070330-29
- Date
- 2007
- Source
- Gene expression patterns : GEP 7(5): 535-543 (Journal)
- Registered Authors
- Crosier, Kathy, Crosier, Phil, Flores, Maria, Hall, Chris
- Keywords
- Rora, Rorb, Rorc, Retinoid-related orphan receptors, Phylogeny, Synteny, Zebrafish, Pineal gland, Retina, Gut, Maternal transcript
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Gene Expression Regulation, Developmental*
- In Situ Hybridization
- Molecular Sequence Data
- Nuclear Receptor Subfamily 1, Group F, Member 2
- RNA Probes
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Receptors, Cytoplasmic and Nuclear/genetics*
- Receptors, Cytoplasmic and Nuclear/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 17374568 Full text @ Gene Expr. Patterns
Citation
Flores, M.V., Hall, C., Jury, A., Crosier, K., and Crosier, P. (2007) The zebrafish retinoid-related orphan receptor (ror) gene family. Gene expression patterns : GEP. 7(5):535-543.
Abstract
The retinoid-related orphan receptors Rora, b and c are highly conserved transcription factors belonging to the steroid hormone receptor superfamily. Mammalian ROR proteins perform key regulatory roles in a number of processes during embryonic development and in the adult including neurogenesis, bone metabolism and modulation of circadian rhythms. A more recent area of interest has been their roles in the development and function of the immune system. In particular, RORA has been implicated in the regulation of inflammatory cytokine production, and RORC has been shown to be essential in the development of the T lymphocyte repertoire and of secondary lymphoid organs. We cloned the zebrafish orthologs for the Ror gene family. Assignment of orthologies was supported by analysis of the phylogenetic relationships between zebrafish and other vertebrate Ror genes based on sequence similarities, and conserved syntenies with the human Ror gene loci.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping