PUBLICATION

The zebrafish retinoid-related orphan receptor (ror) gene family

Authors

Flores, M.V., Hall, C., Jury, A., Crosier, K., and Crosier, P.

ID

ZDB-PUB-070330-29

Date

2007

Source

Gene expression patterns : GEP 7(5): 535-543 (Journal)

Registered Authors

Crosier, Kathy, Crosier, Phil, Flores, Maria, Hall, Chris

Keywords

Rora, Rorb, Rorc, Retinoid-related orphan receptors, Phylogeny, Synteny, Zebrafish, Pineal gland, Retina, Gut, Maternal transcript

MeSH Terms

Sequence Homology, Amino Acid
Nuclear Receptor Subfamily 1, Group F, Member 2
Cloning, Molecular
Zebrafish/embryology
Zebrafish/genetics
Zebrafish/metabolism
In Situ Hybridization
Receptors, Cytoplasmic and Nuclear/genetics*
Receptors, Cytoplasmic and Nuclear/metabolism
Zebrafish Proteins/genetics*
Zebrafish Proteins/metabolism
Molecular Sequence Data
RNA, Messenger/genetics
RNA, Messenger/metabolism
Gene Expression Regulation, Developmental*
RNA Probes
Animals
Amino Acid Sequence
Reverse Transcriptase Polymerase Chain Reaction

PubMed

17374568 Full text @ Gene Expr. Patterns

Abstract

The retinoid-related orphan receptors Rora, b and c are highly conserved transcription factors belonging to the steroid hormone receptor superfamily. Mammalian ROR proteins perform key regulatory roles in a number of processes during embryonic development and in the adult including neurogenesis, bone metabolism and modulation of circadian rhythms. A more recent area of interest has been their roles in the development and function of the immune system. In particular, RORA has been implicated in the regulation of inflammatory cytokine production, and RORC has been shown to be essential in the development of the T lymphocyte repertoire and of secondary lymphoid organs. We cloned the zebrafish orthologs for the Ror gene family. Assignment of orthologies was supported by analysis of the phylogenetic relationships between zebrafish and other vertebrate Ror genes based on sequence similarities, and conserved syntenies with the human Ror gene loci.

Genes / Markers

Figures