ZFIN ID: ZDB-PERS-020710-3
Flores, Maria
Email: m.flores@auckland.ac.nz
URL: http://www.health.auckland.ac.nz/molmedpath/research/crosier.html
Affiliation: Crosier Lab
Address: Rm. 4321, Bldg. 504 Department of Molecular Medicine and Pathology Faculty of Medical and Health Sciences The University of Auckland 85 Park Road, Grafton 1023 Auckland, New Zealand
Country: New Zealand
Phone: 64-9-373-7599 ext. 4480
Fax: 64-9-373-7492
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Oehlers, S.H., Flores, M.V., Hall, C.J., Wang, L., Ko, D.C., Crosier, K.E., Crosier, P.S. (2017) A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. The FEBS journal. 284(3):402-413
Astin, J.W., Jamieson, S.M., Eng, T.C., Flores, M.V., Misa, J.P., Chien, A., Crosier, K.E., Crosier, P.S. (2014) An In Vivo Antilymphatic Screen in Zebrafish Identifies Novel Inhibitors of Mammalian Lymphangiogenesis and Lymphatic-Mediated Metastasis. Molecular cancer therapeutics. 13(10):2450-62
Hall, C.J., Boyle, R.H., Astin, J.W., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Ellett, F., Lieschke, G.J., Crosier, K.E., and Crosier, P.S. (2013) Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production. Cell Metabolism. 18(2):265-278
Oehlers, S.H., Flores, M.V., Hall, C.J., Okuda, K.S., Sison, J.O., Crosier, K.E., and Crosier, P.S. (2013) Chemically Induced Intestinal Damage Models in Zebrafish Larvae. Zebrafish. 10(2):184-93
Okuda, K.S., Astin, J.W., Misa, J.P., Flores, M.V., Crosier, K.E., and Crosier, P.S. (2012) lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development (Cambridge, England). 139(13):2381-2391
Oehlers, S.H., Flores, M.V., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2012) Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis. Disease models & mechanisms. 5(4):457-467
Hall, C.J., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Lam, E.Y., Crosier, K.E., and Crosier, P.S. (2012) Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide. Cell Stem Cell. 10(2):198-209
Crawford, K.C., Flores, M.V., Oehlers, S.H., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Genesis (New York, N.Y. : 2000). 49(12):905-11
Oehlers, S.H., Flores, M.V., Hall, C.J., Swift, S., Crosier, K.E., and Crosier, P.S. (2011) The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Disease models & mechanisms. 4(6):832-41
Oehlers, S.H., Flores, M.V., Chen, T., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) Topographical distribution of antimicrobial genes in the zebrafish intestine. Developmental and comparative immunology. 35(3):385-391
Oehlers, S.H., Flores, M.V., Okuda, K.S., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents. Developmental dynamics : an official publication of the American Association of Anatomists. 240(1):288-298
Flores, M.V., Crawford, K.C., Pullin, L.M., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochemical and Biophysical Research Communications. 400(1):164-168
Lam, E.Y., Hall, C.J., Crosier, P.S., Crosier, K.E., and Flores, M.V. (2010) Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells. Blood. 116(6):909-914
Flores, M.V., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies. Developmental dynamics : an official publication of the American Association of Anatomists. 239(7):2128-2135
Oehlers, S.H., Flores, M.V., Hall, C.J., O'Toole, R., Swift, S., Crosier, K.E., and Crosier, P.S. (2010) Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation. Developmental and comparative immunology. 34(3):352-359
Hall, C., Flores, M.V., Chien, A., Davidson, A., Crosier, K., and Crosier, P. (2009) Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages. Journal of Leukocyte Biology. 85(5):751-765
Lam, E.Y., Chau, J.Y., Kalev-Zylinska, M.L., Fountaine, T.M., Mead, R.S., Hall, C.J., Crosier, P.S., Crosier, K.E., and Flores, M.V. (2009) Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors. Blood. 113(6):1241-1249
Hall, C., Flores, M.V., Crosier, K., and Crosier, P. (2009) Live cell imaging of zebrafish leukocytes. Methods in molecular biology (Clifton, N.J.). 546:255-271
Hall, C.J., Flores, M.V., Crosier, K.E., and Crosier, P.S. (2008) Live imaging early immune cell ontogeny and function in zebrafish Danio rerio. Journal of Fish Biology. 73(8):1833-1871
Flores, M.V., Hall, C.J., Davidson, A.J., Singh, P.P., Mahagaonkar, A.A., Zon, L.I., Crosier, K.E., and Crosier, P.S. (2008) Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2. Gastroenterology. 135(5):1665-1675
Cvejic, A., Hall, C., Bak-Maier, M., Flores, M.V., Crosier, P., Redd, M.J., and Martin, P. (2008) Analysis of WASp function during the wound inflammatory response - live-imaging studies in zebrafish larvae. Journal of Cell Science. 121(Pt 19):3196-3206
Flores, M.V., Lam, E.Y., Crosier, K.E., and Crosier, P.S. (2008) Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish. Nature cell biology. 10(3):346-352
Hall, C., Flores, M.V., Storm, T., Crosier, K., and Crosier, P. (2007) The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish. BMC Developmental Biology. 7(1):42
Flores, M.V., Hall, C., Jury, A., Crosier, K., and Crosier, P. (2007) The zebrafish retinoid-related orphan receptor (ror) gene family. Gene expression patterns : GEP. 7(5):535-543
Hall, C., Flores, M.V., Murison, G., Crosier, K., and Crosier, P. (2006) An essential role for zebrafish Fgfrl1 during gill cartilage development. Mechanisms of Development. 123(12):925-940
Flores, M.V., Lam, E.Y., Crosier, P., and Crosier, K. (2006) A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 235(11):3166-3176
Flores, M.V., Tsang, V.W., Hu, W., Kalev-Zylinska, M., Postlethwait, J., Crosier, P., Crosier, K., and Fisher, S. (2004) Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene expression patterns : GEP. 4(5):573-581
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V., Postlethwait, J.H., Chau, J.Y., Cattin, P.M., Vitas, M.R., Crosier, P.S., and Crosier, K.E. (2003) Runx3 is required for hematopoietic development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):323-336
Hall, C.J., Flores, M.V.C., Davidson, A.J., Crosier, K.E., and Crosier, P.S. (2002) Radar is required for the establishment of vascular integrity in the zebrafish. Developmental Biology. 251(1):105-117
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development (Cambridge, England). 129(8):2015-2030
Crosier, P.S., Kalev-Zylinska, M.L., Hall, C.J., Flores, M.V.C., Horsfield, J.A., and Crosier, K.E. (2002) Pathways in blood and vessel development revealed through zebrafish genetics. The International journal of developmental biology. 46(4):493-502
Kalev, M.L., Horsfield, J.A., Flores, M.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2001) Runt family transcription factors are required for zebrafish hematopoiesis, and their function is disrupted by a human RUNX1-CBF2T1 transgene. Blood. 98(11):1892

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