PUBLICATION
The HeArt of Regeneration
- Authors
- Curado, S., and Stainier, D.Y.
- ID
- ZDB-PUB-061108-11
- Date
- 2006
- Source
- Cell 127(3): 462-464 (Journal)
- Registered Authors
- Stainier, Didier
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Animals, Outbred Strains
- Cell Differentiation
- Heart/physiology*
- Heart Injuries/pathology
- Heart Injuries/physiopathology
- Heart Ventricles/pathology
- Heart Ventricles/physiopathology
- Male
- Models, Cardiovascular
- Myocardium/metabolism
- Myocardium/pathology
- Pericardium/injuries*
- Regeneration/genetics
- Regeneration/physiology*
- Stem Cells/physiology*
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 17081969 Full text @ Cell
Citation
Curado, S., and Stainier, D.Y. (2006) The HeArt of Regeneration. Cell. 127(3):462-464.
Abstract
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this process remain unclear. In this issue of Cell, analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for the epicardium, the cellular layer that covers the heart.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping